Evidence map›Paper›PMID 40085355›Full record

ArticleMolecular neurobiology2025

Proteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis.

Piyumi B Wijesiri Gunawardana, Khyati Gohil, Kyung-Mee Moon, Leonard J Foster, Florence J Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Piyumi B Wijesiri GunawardanaDepartment of Chemistry, University of Iowa, Iowa City, IA, USA.
Khyati GohilDepartment of Chemistry, University of Alberta, Edmonton, AB, Canada.
Kyung-Mee MoonDepartment of Biochemistry & Molecular Biology, University of British Colombia, Vancouver, Canada.
Leonard J FosterDepartment of Biochemistry & Molecular Biology, University of British Colombia, Vancouver, Canada.
Florence J WilliamsDepartment of Chemistry, University of Iowa, Iowa City, IA, USA. florence-williams@uiowa.edu.

Funding

A Mechanistic Foundation for the Iron Homeostasis Impacts and Neurotrophic Activity of trans-BangleneR21AG083334 · NIA · UNIVERSITY OF IOWA · PI EPP, JONATHAN RICHARD, WILLIAMS, FLORENCE JUDITH · 2024 to 2024
$386k
Canada Research Coordinating Committee NFRFE-2018-00223Genome Canada 264PRONIA NIH HHS 1R21AG083334-01A1NIA NIH HHS R21 AG083334
6 · The paper itself

Abstract

In an effort to gain insight into cellular systems impacted by neurotrophic trans-banglene (t-BG), global proteomic profiling and Western blot analyses were employed. Expression level changes in response to t-BG treatment were compared to those observed with nerve growth factor (NGF), a natural neurotrophic protein and functional analog to t-BG. Findings from these studies did not point to direct interception of NGF/TrkA signaling by t-BG. Instead, significant alterations in iron-binding and iron-regulating proteins were observed. While total iron levels showed no change across all treatments, intracellular iron measurements and mitochondrial iron measurements demonstrated lower ferrous (Fe

Indexed as

HomeostasisIronProteomicsAnimalsMitochondriaNerve Growth FactorPC12 CellsRatsIronNerve Growth FactorBangleneGlobal proteomic profilingIron homeostasisNeurodegenerative diseaseNGFTrkA signalingWestern blots

Identifiers

PMID40085355
PMCPMC12512878

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.