Evidence map›Paper›PMID 40085327›Full record

ArticleBiogerontology2025

Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats.

Ram Prajit, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat

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Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ram PrajitFaculty of Medicine, Department of Anatomy, Neurogenesis Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand.
Nataya SritawanFaculty of Medicine, Department of Anatomy, Neurogenesis Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand.
Anusara AranarochanaFaculty of Medicine, Department of Anatomy, Neurogenesis Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand.
Apiwat SirichoatFaculty of Medicine, Department of Anatomy, Neurogenesis Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand.
Wanassanun PannangrongFaculty of Medicine, Department of Anatomy, Khon Kaen University, Khon Kaen, 40002, Thailand.
Peter WigmoreSchool of Life Sciences, Queen's Medical Centre, Medical School, University of Nottingham, Nottingham, NG7 2RD, UK.
Jariya Umka WelbatFaculty of Medicine, Department of Anatomy, Neurogenesis Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand. jariya@kku.ac.th.ORCID 0000-0002-2872-1542

Funding

Invitation Research of the Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand IN68027Royal Golden Jubilee (RGJ) Ph.D. Programme N41A650079
6 · The paper itself

Abstract

Aged-related cognitive impairments are associated with molecular neurodegenerations and impeded neurogenesis in the dentate gyrus (DG) of the damaged hippocampus. Neurogenesis requires activated cyclic AMP-responsive element-binding protein (CREB) pathway to enhance neuronal development, synaptic plasticity, cognition, learning and memory. Current research has reported that consecutive administration of D-galactose can accelerate brain aging by inducing oxidation and inflammation. The flavonoid chrysin has been demonstrated in medical dietary supplements and shown neuroprotective effect on impeded neurogenesis. This study aimed to clarify that chrysin preserves neurogenesis by modulating molecular pathway in accelerated brain aging induced by D-galactose. Signs of aging, processes of neurogenesis, and protein regulating neurogenesis were evaluated in male Sprague Dawley (SD) rats, which were allocated into four groups: vehicle rats, accelerated aging rats treated with D-galactose, normal rats receiving chrysin, and cotreated rats receiving both D-galactose and chrysin. Aging signs showed only a subsidence in volume of the granular cell layer (GCL) after consecutive administration of D-galactose. Cell proliferation, neurogenic niches, and protein regulating proliferation were downregulated in the accelerated aging rats. Likewise, cell survivals and proteins related to CREB pathway were depleted in rats receiving D-galactose. Nevertheless, rats cotreated with chrysin maintained in all parameters that were adversely affected by D-galactose. In conclusion, chrysin could alleviate the disruption of molecular regulation of neurogenesis in accelerated brain aging induced by D-galactose.

Indexed as

AgingBrainDentate GyrusFlavonoidsGalactoseNeurogenesisNeuroprotective AgentsAnimalsCell ProliferationCyclic AMP Response Element-Binding ProteinMaleRatsRats, Sprague-DawleychrysinCyclic AMP Response Element-Binding ProteinFlavonoidsGalactoseNeuroprotective AgentsBrain agingCell proliferationCell survivalChrysinD-galactoseNeurogenesis

Identifiers

PMID40085327

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.