Evidence map›Paper›PMID 40085326›Full record

ArticleInternational ophthalmology2025

Quality of life in patients with progressive keratoconus treated with corneal collagen crosslinking.

J Steinberg, P Fischer, A Frings, V Druchkiv, T Katz, S J Linke

Abstract read
In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Evaluation of Factors Influencing Quality of Life in Keratoconus Patients Using the Keratoconus Outcomes Research Questionnaire (KORQ).Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J SteinbergDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. steinberg@hamburgvisionclinic.com.ORCID http://orcid.org/0000-0002-3091-9347
P FischerDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
A FringsDepartment of Ophthalmology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
V DruchkivDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
T KatzDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
S J LinkeDepartment of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to analyze the vision-related quality of life (vr-QoL) in keratoconus (KC) patients after corneal crosslinking (CXL).

methodsA prospective clinical study was conducted, wherein 41 patients underwent assessment using the "National Eye Institute Visual Functioning Questionnaire" (NEI-25) and the "Keratoconus Outcomes Research Questionnaire" (KORQ) to evaluate vr-QoL, along with the examination of morphology and functional parameters before CXL, and at three and six months post-treatment. Rasch analyses were used to verify the measurement precision of the KORQ with our study population.

resultsThere were no statistically significant changes observed in corneal morphology and best corrected visual acuity after CXL. Analysis of the NEI-25 questionnaires and KORQ demonstrated no statistically significant changes throughout the follow-up period. Rasch analyses revealed a high measurement precision of the KORQ within our population.

conclusionThe study indicates that patients with progressive KC maintain stable vr-QoL after undergoing CXL. Based on our findings, we suggest considering very early CXL treatment for KC patients that are at high risk of progression.

Indexed as

CollagenCorneaCross-Linking ReagentsKeratoconusPhotochemotherapyQuality of LifeRiboflavinAdolescentAdultCorneal StromaCorneal TopographyDisease ProgressionFemaleFollow-Up StudiesHumansMaleCollagenCross-Linking ReagentsPhotosensitizing AgentsRiboflavinCorneal crosslinkingKeratoconusKORQNEI-25Vision-related quality of life

Identifiers

PMID40085326
PMCPMC11909072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.