Evidence map›Paper›PMID 40085243›Full record

ArticleActa neuropathologica2025

Constitutional variants in PTEN: a frequent finding in patients with papillary tumors of the pineal region subtype B (PTPR-B) associated with isolated loss of chromosome 10.

Steffen Hirsch, Ramin Rahmanzade, Kerstin Grund, Christian Sutter, Kathrin Schramm, Florian Selt, Jonas Ecker, Barbara C Jones, Daniel Schrimpf, Martin Demmert and 16 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Steffen Hirsch *Institute of Human Genetics, Heidelberg University, Heidelberg, Germany. steffen.hirsch@med.uni-heidelberg.de.
Ramin Rahmanzade *Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Kerstin GrundInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Christian SutterInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Kathrin SchrammDepartment of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Florian SeltDepartment of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Jonas EckerDepartment of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Barbara C JonesDepartment of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Daniel SchrimpfDepartment of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Martin DemmertDepartment of Pediatric Oncology, University Hospital Schleswig Holstein - Lübeck, Lübeck, Germany.
Ana S Guerreiro StücklinDepartment of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Pablo Hernaiz DrieverDepartment of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Markus MezgerDepartment of General Pediatrics, Hematology and Oncology, University Children's Hospital, Tübingen, Germany.
Ines BrechtDepartment of General Pediatrics, Hematology and Oncology, University Children's Hospital, Tübingen, Germany.
Sasan D AdibDepartment of Neurosurgery, University of Tuebingen, Tübingen, Germany.
Bastian BrummelDepartment of Pediatric Oncology and Hematology, Klinikum Dortmund, Dortmund, Germany.
Dominik SturmDepartment of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Nicola DikowInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Maja HempelInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Till MildeHopp Children's Cancer Center Heidelberg (KiTZ) and Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Kristian PajtlerHopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
David T W JonesHopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefan M PfisterHopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Felix SahmDepartment of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Christian P SchaafInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40085243
PMCPMC11909084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.