Evidence map›Paper›PMID 40085238›Full record

ArticleActa neuropathologica2025

High resolution autoradiography of [

Sujala Ghatamaneni, Courtney Coleman, Ian Shin, Tyler Bruinsma, Nancy Scott, Jeyeon Lee, Ping Fang, Hoon-Ki Min, Christina M Moloney, Ashley C Wood and 11 more

Abstract read
In one paragraph

Article in Acta neuropathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. High-resolution [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Tau PET overlap index correlation with neuropathological findings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sujala Ghatamaneni *Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Courtney Coleman *Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Ian Shin *Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Tyler BruinsmaDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Nancy ScottDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Jeyeon LeeDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Ping FangDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Hoon-Ki MinDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Christina M MoloneyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ashley C WoodDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Eleni ConstantopoulosDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ross R ReichardDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA. vlowe@mayo.edu.

Funding

Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
NIA NIH HHS R37 AG011378
6 · The paper itself

Abstract

Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer's disease (AD). The maturity level of neurofibrillary tangles can affect its recognition by biomarkers. Early detection of tau aggregates regarding tangle pathology is of interest in early diagnosis and comparison of tau radiotracers in this aspect is important. This study focused on head to head pathologic comparison of [

Indexed as

Alzheimer DiseaseBrainCarbolinesNeurofibrillary TanglesAgedAged, 80 and overAutoradiographyFemaleHumansIsoquinolinesMaleMiddle AgedPositron-Emission Tomographytau Proteins7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinesIsoquinolinesMK-6240tau Proteins[18F]Flortaucipir[18F]MK-6240Alzheimer’s diseaseAtypical Alzheimer’s diseaseCorticobasal degenerationFrontotemporal dementiaMAPT mutationProgressive supranuclear palsyR406WsvPPATauTauopathy

Identifiers

PMID40085238
PMCPMC11909026

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.