Evidence map›Paper›PMID 40085227›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Spontaneous regression of epileptogenic pilocytic astrocytoma with FGFR1-TACC1 fusion.

Ko Horikoshi, Yasushi Iimura, Hiroharu Suzuki, Mario Suzuki, Hidenori Sugano, Akihide Kondo

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ko HorikoshiDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan.
Yasushi IimuraDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan. yiimura@juntendo.ac.jp.
Hiroharu SuzukiDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan.
Mario SuzukiDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan.
Hidenori SuganoDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan.
Akihide KondoDepartment of Neurosurgery, Juntendo University, 2-1-1Bunkyo-Ku, Hongo, Tokyo, 113-8421, Japan.

Funding

MHLW Research program on rare and intractable diseases JPMH23FC1013
6 · The paper itself

Abstract

introductionPilocytic astrocytoma (PA) is the most common pediatric tumor, typically located in the cerebellum, with spontaneous regression observed mainly in patients with neurofibromatosis type 1 (NF1). However, spontaneous regression of PA without NF1 is rarely reported. CASE PRESENTATION: Here, we describe a case of spontaneous regression of PA without NF1, located in the left frontal lobe with FGFR1-TACC1 fusion, in a 14-year-old boy who presented with epilepsy. Initial MRI revealed a lesion in the left middle frontal gyrus, and subsequent follow-up MRI demonstrated spontaneous regression. Despite this regression, the patient's seizures persisted, leading to epileptic focus resection. Pathological examination confirmed PA with characteristic histological findings and FGFR1-TACC1 fusion.

conclusionThis case suggests that FGFR1-TACC1 fusion may be linked to spontaneous regression of PA, even in the absence of NF1. Surgical intervention may remain necessary in cases of epilepsy associated with PA, regardless of tumor regression.

Indexed as

AstrocytomaBrain NeoplasmsEpilepsyNeoplasm Regression, SpontaneousReceptor, Fibroblast Growth Factor, Type 1AdolescentHumansMagnetic Resonance ImagingMaleFGFR1 protein, humanReceptor, Fibroblast Growth Factor, Type 1EpilepsyFGFR1-TACC1 fusionPilocytic astrocytomaSpontaneous regression

Identifiers

PMID40085227
PMCPMC11909081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.