Evidence map›Paper›PMID 40085185›Full record

SynthesisObesity surgery2025

One Anastomosis Gastric Bypass Versus Roux‑en‑Y Gastric Bypass for Obesity: An Updated Meta‑analysis and Systematic Review of Randomized Controlled Trials.

Yusuf Ahmed, Karim Ataya, Abdulla Almubarak, Isa Almubarak, Manar Ali, Walaa Yusuf, Mostafa Mohammed Saad Mahran, Stefan Simeonovski, Almoutuz Aljaafreh, Wah Yang

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yusuf AhmedDammam Medical Complex, Dammam, Saudi Arabia. yusufaliahmed619@gmail.com.
Karim AtayaHomerton University Hospital, London, UK. Karimataya@outlook.com.
Abdulla AlmubarakMansoura University, Al Mansurah, Egypt.
Isa AlmubarakAl Kindi Hospital, Manama, Bahrain.
Manar AliMansoura University, Al Mansurah, Egypt.
Walaa YusufDammam Medical Complex, Dammam, Saudi Arabia.
Mostafa Mohammed Saad MahranHomerton University Hospital, London, UK.
Stefan SimeonovskiMilitary Medical Academy, Sofia, Bulgaria.
Almoutuz AljaafrehSt George'S University Hospitals NHS Foundation Trust, London, UK.
Wah YangDepartment of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China. yangwah@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRoux-en-Y gastric bypass (RYGB) is widely regarded as a cornerstone intervention for individuals afflicted with metabolic syndromes and severe obesity. However, one anastomosis gastric bypass (OAGB) emerged after RYGB as a more straightforward and less technically demanding operation. This systematic review and meta-analysis aims to compare both procedures and update the currently existing evidence.

methodsWe systematically searched PubMed, Scopus, and the Cochrane Central Register for randomized controlled trials (RCTs) that compared OAGB with RYGB as primary operations.

resultsTwelve studies were included in this meta-analysis, with a total of 904 patients. Total weight loss percentage (TWL%) was statistically higher in the OAGB group at 6 months (95% CI 0.80 to 2.94; P = 0.006) with no differences in 12, 24, and 36 months compared to RYGB. On the other hand, OAGB exhibited a significantly higher excess weight loss percentage (EWL%) compared to RYGB at 12 months (95% CI 3.08 to 9.73; P = 0.0002). EWL% was comparable in both procedures at 6, 24, and 60 months of follow-up. There were no statistically significant differences in terms of the resolution of comorbidities related to obesity. De novo gastro-esophageal reflux disease (GERD) (RR 2.58; 95% CI 1.55 to 4.3; P = 0.0003) and marginal ulcers (RR 2.7; 95% CI 1.07 to 6.84; P = 0.04) were significantly higher in patients who underwent OAGB in comparison to RYGB.

conclusionsIn conclusion, OAGB is comparable to RYGB in terms of weight loss parameters and comorbidity resolution. However, OAGB can lead to a higher risk of development of marginal ulcers and de novo GERD.

Indexed as

Gastric BypassObesity, MorbidPostoperative ComplicationsHumansRandomized Controlled Trials as TopicTreatment OutcomeWeight LossOne anastomosis gastric bypassRoux-en-Y gastric bypassWeight loss

Identifiers

PMID40085185

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.