Trial reportNeuro-oncology2025
Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery.
Trial report in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03636568 (Early Fluid Restriction to Prevent Delayed Hyponatremia Following Pituitary Surgery), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Fluid Restriction to Prevent Delayed Hyponatremia Following Pituitary Surgery
Who cites it
4 citing papers in PubMed.
- The Limited Role of Hypocortisolism in the Development of Delayed Postoperative Hyponatremia After Pituitary Surgery.Pituitary · 2026Article
- Postoperative delayed hyponatremia after endoscopic transsphenoidal surgery for pituitary adenomas: role of fluid restriction and associated risk factors.Frontiers in endocrinology · 2026Article
- Predictors of delayed hyponatremia after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas.Frontiers in endocrinology · 2025Article
- Predictive model of delayed hyponatremia after endoscopic endonasal transsphenoidal resection of pituitary adenoma.Frontiers in human neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
backgroundReadmission following endoscopic endonasal transsphenoidal surgery (EETS) for pituitary neuroendocrine tumor (PitNET) and other sellar pathology is most commonly due to delayed hyponatremia. Studies suggest postoperative fluid restriction (FR) reduces delayed hyponatremia. We present a prospective randomized controlled study evaluating post-EETS FR.
methods300 participants were scheduled for EETS (2016-2023) at a single institution. Patients with CKD, CHF, arginine vasopressin deficiency on postoperative day (POD) 3, chronic hyponatremia, and untreated adrenal insufficiency or hypothyroidism were excluded. Groups included control (ad-lib, n = 94), moderate FR (1.8 L/day or 2 L/day weight > 100 kg, n = 39), and strict FR (1 L/day or 1.2 L/day weight > 100 kg, n = 62) from POD 3-14. Incidence of overall, moderate, and severe hyponatremia (Na < 135, 125-129, and <125 mEq/L), readmission rates, fluid intake, and thirst were evaluated.
resultsThe incidence of overall hyponatremia was 31.9%, 28.2%, and 21.0% in control, moderate FR, and strict FR groups, and the incidence of severe hyponatremia was 7.4%, 5.1%, and 0% in control, moderate FR, and strict FR groups. Nadir Na level was higher (1.81 mEq/L; 95% CI, 0.34 to 3.27; P = .02) and severe hyponatremia occurred less frequently (95% CI, 0.00 to 1.02; P = .04) in the strict FR vs. control group. Readmission was lower in the strict FR (1.6%, n = 1) vs. control group (6.4%, n = 6).
conclusionsPostoperative FR decreases rates of delayed hyponatremia and related readmission compared to patients drinking ad-lib. Further studies are needed to assess the optimal volume and duration of FR after EETS. Trial registration number: NCT03636568.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.