Evidence map›Paper›PMID 40084878›Full record

ArticleAntimicrobial agents and chemotherapy2025

Siglec-targeted liposomes to identify sialoglycans present on fungal pathogens.

Suresh Ambati, Quanita J Choudhury, Jesse Ann Peter, Kelley W Moremen, Digantkumar Gopaldas Chapla, Zachary A Lewis, Xiaorong Lin, Richard B Meagher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suresh AmbatiDepartment of Genetics, University of Georgia, Athens, Georgia, USA.
Quanita J ChoudhuryDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.
Jesse Ann PeterDepartment of Genetics, University of Georgia, Athens, Georgia, USA.
Kelley W MoremenDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Digantkumar Gopaldas ChaplaDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Zachary A LewisDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-1735-8266
Xiaorong LinDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-3390-8387
Richard B MeagherDepartment of Genetics, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-3928-8403

Funding

Targeted Pan-Antifungal LiposomesR01AI162989 · NIAID · UNIVERSITY OF GEORGIA · PI Zachary Lewis, Richard Brian Meagher · 2022 to 2026
$2.6M
Antifungal Liposomes Targeted to Cell Wall MannansR21AI148890 · NIAID · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN · 2020 to 2021
$415k
Targeted delivery of antifungal drug loaded liposomes to control mucormycosisR21AI171787 · NIAID · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN · 2022 to 2023
$415k
Antifungal ImunoliposomesR21AI144498 · NIAID · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN · 2019 to 2020
$415k
NIAID NIH HHS R01 AI162989NIAID NIH HHS R21 AI144498NIAID NIH HHS R21 AI148890NIAID NIH HHS R21 AI171787NIH HHS R01AI162989NIH HHS R21AI171787
6 · The paper itself

Abstract

The sialic acid Ig-like lectins Siglec-3 and Siglec-15 are pathogen receptors that bind sialic acid-modified glycoproteins, best characterized in metastatic cancers. Because fungi produce sialoglycans and sialo-glycoproteins, we wondered if Siglecs had the potential for targeted delivery of antifungal drugs. We purified the extracellular V-region Ig-like C2 ligand-binding domains and stalk regions of SIG3 and SIG15. We floated the two polypeptides on the surface of liposomes loaded with amphotericin B (AmB) and labeled with rhodamine B to prepare SIG3-Ls and SIG15-Ls. Using these two reagents, we explored the sialoglycans of two evolutionarily distant and deadly human fungal pathogens, the Mucormycete

Indexed as

Aspergillus fumigatusLiposomesSialic Acid Binding Immunoglobulin-like LectinsAmphotericin BAntifungal AgentsFungal ProteinsHumansLectinsAmphotericin BAntifungal AgentsFungal ProteinsLectinsLiposomesSialic Acid Binding Immunoglobulin-like Lectinsamphotericin Bantifungal agentsfungiliposomesNeu5Acpathogenssialic acidsialo-glycoproteinSiglectargeted

Identifiers

PMID40084878
PMCPMC11963605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.