ReviewCardiovascular research2025
Blood pressure and the brain: the conundrum of hypertension and dementia.
Review in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes of antihypertensive medication use in people with dementia: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Intensive BP Control and Cognitive Function: A Randomized Clinical Trial.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Hypertensive Disorders of Pregnancy and Incident Dementia.JAMA network open · 2026Article
- Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.Brain imaging and behavior · 2026Article
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Cohort profile: a community-based prospective cohort study of Alzheimer's disease and related dementias in the Democratic Republic of Congo.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.Cardiovascular research · 2026Review
- Predictors of cognitive resilience in the old-old: An observational study using real-world electronic health record data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Hypertensive Brain Injury as a Journey Not a Destination.Journal of the American Heart Association · 2026Article
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Arterial Hypertension as a Modulator of Cognitive Response to CPAP Therapy in Moderate-to-Severe Obstructive Sleep Apnea.Medicina (Kaunas, Lithuania) · 2026Article
- Neuroendocrine-vascular interaction is associated with thalamocortical disorganization and cognitive decline in perimenopausal hypertension.Frontiers in medicine · 2026Article
- Barriers and facilitators of hypertension control among older adults living with hypertension: A mixed-methods study.PLOS global public health · 2026Article
- Differential Risks of Dementia, Depression, and Injury Among Common α-Blockers, with Tamsulosin as the Reference Drug: A Real-World Cohort Study in Men with Lower Urinary Tract Symptoms.Journal of clinical medicine · 2025Article
- Young-Onset Dementia: Clinical Findings and Factors That Delay Early Diagnosis-A Retrospective Observational Study.Biomedicines · 2025Article
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management.Biomolecules · 2025Review
- Alzheimer's disease model explains Alzheimer's disease incidences.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
As the population ages, the anticipated rates of dementia worldwide are likely to increase dramatically, especially in low- and middle-income countries; thus, any opportunity to modify dementia risk is especially critical. Hypertension is one risk factor that is highly prevalent, consistently important for late-life brain health, and which could represent a target for prevention of dementia. Furthermore, hypertension is the most significant modifiable risk factor for stroke. This review will summarize existing literature linking hypertension with dementia and brain health more broadly, will discuss potential mechanisms linking hypertension with brain health, and will consider specific factors that may impact not only the relationship between hypertension and the brain but also the importance of treatment, including different associations over the life course.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.