Evidence map›Paper›PMID 40084686›Full record

ArticleInternational journal of molecular medicine2025

Hesperetin induces apoptosis in lung squamous carcinoma cells via G

Qianlong Xie, Ziming He, Lingfang Tan, Min Li, Min Zhuang, Chen Liu, Sunhui Chen, Long Jin, Yuxia Sui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. From Single-Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qianlong XieDepartment of Pharmacy, Wuping County Hospital, Longyan, Fujian 363400, P.R. China.
Ziming HeSchool of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350122, China.
Lingfang TanSchool of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350122, China.
Min LiDepartment of Clinical Laboratory, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.
Min ZhuangSchool of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350122, China.
Chen LiuSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China.
Sunhui ChenDepartment of Pharmacy, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.
Long JinDepartment of Pathology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.
Yuxia SuiDepartment of Pharmacy, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hesperetin (HST), a natural flavonoid, has potent antitumor effects on lung adenocarcinoma; however, its effects on lung squamous cell carcinoma (LUSC) are currently unknown. The present study aimed to investigate the anticancer effects of HST on LUSC cells. The influence of 37.5, 75 and 150

Indexed as

ApoptosisCarcinoma, Squamous CellEndoplasmic Reticulum StressG2 Phase Cell Cycle CheckpointsHesperidinLung NeoplasmsReceptor, Notch1Signal TransductionAnimalsCell Line, TumorHumansMaleMiceMice, Inbred BALB CMice, NudeXenograft Model Antitumor AssayshesperetinHesperidinNOTCH1 protein, humanReceptor, Notch1apoptosisendoplasmic reticulum stressG2/M phase arresthesperetinlung squamous cell carcinomaNotch1 pathway

Identifiers

PMID40084686
PMCPMC11936485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.