ArticleInternational journal of urology : official journal of the Japanese Urological Association2025
Peritumoral Infiltration of Regulatory T Cells Reduces the Therapeutic Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Carcinoma In Situ.
Article in International journal of urology : official journal of the Japanese Urological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Foxp3+/CD4+ Cell Ratio in Primary Colorectal Cancer Predicts Opposite Prognoses Following Resection of Synchronous or Metachronous Liver Metastases.Cancer medicine · 2026Article
- CD39/CD73-mediated immunosuppression and tumor aggressiveness in bladder cancer.Cancer immunology, immunotherapy : CII · 2026Article
- Regulatory T cells in the bladder cancer tumor microenvironment: mechanisms of immune suppression and therapeutic opportunities.Frontiers in molecular biosciences · 2026Review
- Editorial Comment on "Peritumoral Infiltration of Regulatory T Cells Reduces the Therapeutic Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Carcinoma In Situ".International journal of urology : official journal of the Japanese Urological Association · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
objectivesIntravesical instillation of bacillus Calmette-Guérin (BCG) is the standard treatment for bladder carcinoma in situ (CIS); however, factors that predict its therapeutic efficacy have not been identified. We focused on immune cells infiltrating within 20 μm of tumor cells and examined factors that predict the efficacy of intravesical BCG treatment.
methodsFormalin-fixed, paraffin-embedded tissue specimens from 82 patients with bladder CIS treated with intravesical BCG were used. Patients who relapsed after BCG treatment were grouped as non-responders, and those who did not were grouped as responders. Tissue sections were immunostained for CD4, CD8, and forkhead box P3 (FOXP3), a marker of regulatory T cells (Tregs). The number of immune cells positive for the above markers present within 20 μm of the lower edge of the basement membrane on which CIS is present was counted and compared between groups.
resultsBoth the peritumoral Treg density and Treg+/CD4+ cell ratio were significantly greater in nonresponders than in responders. The patients were divided into high and low groups based on Treg density and Treg+/CD4+ cell ratio cut-off values; recurrence-free survival was significantly longer in the low group than in the high group (p = 0.005 and p < 0.001, respectively).
conclusionsThe Treg density and Treg+/CD4+ cell ratio within 20 μm of bladder CIS may be useful predictors of therapeutic response to BCG.
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