Evidence map›Paper›PMID 40084553›Full record

ReviewJournal of investigative medicine high impact case reports

Fatal Pulmonary Failure-A Rare Case of Blastomycosis Induced Acute Respiratory Distress Syndrome: A Case Report and Literature Review.

Sinen Zeleke, Leen Kayali, Ean Bills, Saron Tigabe, Andy White, Victoria Watson, Fuad Zeid, Zakaria Alagha

Abstract readCase ReportsReview
In one paragraph

Review in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sinen ZelekeMarshall University, Huntington, WV, USA.
Leen KayaliMarshall University, Huntington, WV, USA.
Ean BillsMarshall University, Huntington, WV, USA.ORCID 0009-0008-9419-5772
Saron TigabeMarshall University, Huntington, WV, USA.
Andy WhiteMarshall University, Huntington, WV, USA.
Victoria WatsonMarshall University, Huntington, WV, USA.
Fuad ZeidMarshall University, Huntington, WV, USA.
Zakaria AlaghaMarshall University, Huntington, WV, USA.ORCID 0009-0002-1092-3565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blastomycosis is a systemic fungal infection caused by Blastomyces dermatitidis, primarily found in the Ohio and Mississippi River valleys. It often presents nonspecific symptoms, and while pulmonary involvement is common, progression to acute respiratory distress syndrome (ARDS) is rare but severe. This report examines a 55-year-old female patient with multiple comorbidities who developed ARDS due to blastomycosis. Imaging revealed multilobar infiltrates and pleural effusion, with cultures confirming blastomycosis. Despite broad-spectrum antibiotics and antifungal therapy, a delayed diagnosis led to respiratory failure and death. The case emphasizes the diagnostic challenges of blastomycosis, which can mimic conditions like bacterial pneumonia and malignancy. Treatment with amphotericin B is crucial for severe cases, but delays in diagnosis can worsen outcomes. This highlights the necessity for prompt diagnosis and comprehensive management, including early recognition of fungal infections in critically ill patients.

Indexed as

BlastomycosisRespiratory Distress SyndromeAmphotericin BAntifungal AgentsBlastomycesDelayed DiagnosisDiagnosis, DifferentialFatal OutcomeFemaleHumansMiddle AgedTomography, X-Ray ComputedAmphotericin BAntifungal Agentsacute respiratory distress syndrome (ARDS)blastomycosiscomorbiditiesfungal infectionrespiratory failure

Identifiers

PMID40084553
PMCPMC11909673

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.