Evidence map›Paper›PMID 40084552›Full record

ArticleBipolar disorders2025

White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits.

Audrey Berardi, Jennifer A Brown, Brooke S Jackson, Ling-Yu Huang, Rebekah L Trotti, David A Parker, Scot K Hill, Elena Ivleva, Godfrey D Pearlson, Carol A Tamminga and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Audrey BerardiDepartment of Psychology, University of Georgia, Athens, Georgia, USA.ORCID 0009-0004-7811-3109
Jennifer A BrownDepartment of Psychology, University of Georgia, Athens, Georgia, USA.
Brooke S JacksonDepartment of Psychology, University of Georgia, Athens, Georgia, USA.
Ling-Yu HuangBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Rebekah L TrottiBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
David A ParkerDepartment of Psychology, University of Georgia, Athens, Georgia, USA.
Scot K HillDepartment of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, Illinois, USA.
Elena IvlevaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Godfrey D PearlsonThe Institute of Living, Hartford, Connecticut, USA.
Carol A TammingaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Sarah K KeedyDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
John A SweeneyDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA.
Brett A ClementzDepartment of Psychology, University of Georgia, Athens, Georgia, USA.
Jennifer E McDowellDepartment of Psychology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-8134-3678

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Psychosis-related Physiological and Neuronal Phenotypes in 22q11 Deletion SyndromeR01MH117315 · NIMH · EMORY UNIVERSITY · PI CUBELLS, JOSEPH F., DUNCAN, ERICA J · 2019 to 2023
$3.4M
3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096957 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2013 to 2015
$983k
Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096913 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2013 to 2015
$950k
4/6 Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096942 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KESHAVAN, MATCHERI S. · 2013 to 2015
$783k
4/4-Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096900 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A · 2013 to 2015
$223k
A data-driven framework for mapping transcranial electrical stimulation effects on audiovisual integration and hallucinationsF32MH135669 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TROTTI, REBEKAH LYN · 2024 to 2025
$149k
NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NIMH NIH HHS F32 MH135669NIMH NIH HHS MH096900NIMH NIH HHS MH096913NIMH NIH HHS MH096942NIMH NIH HHS MH096957NIMH NIH HHS MH117315NIMH NIH HHS R01 MH096900NIMH NIH HHS R01 MH096913NIMH NIH HHS R01 MH096942NIMH NIH HHS R01 MH096957NIMH NIH HHS R01 MH117315NIMH NIH HHS TL1TR002382NIMH NIH HHS UL1TR002378
6 · The paper itself

Abstract

aimThis study aimed to evaluate associations in bipolar disorder (BD) across multimodal measures of white matter microstructure (using diffusion tensor imaging; DTI), cognitive, behavioral, and brain electrophysiological measures (using electroencephalography; EEG).

methodsSubjects were recruited through the Psychosis and Affective Research Domains and Intermediate Phenotypes Consortium (n = 45 bipolar with psychosis, n = 40 bipolar without psychosis, n = 66 healthy subjects). DTI data were used to quantify the white matter variables, fractional anisotropy (FA) and radial diffusivity (RD). The Brief Assessment of Cognition in Schizophrenia (BACS), Stop Signal Task (SST), pro- and anti-saccades, auditory event-related potentials (ERPs), and intrinsic brain activity were used as estimates of brain function.

resultsThe combined BD group differed from healthy controls, but no differences between BD with and without psychosis were observed. BD-related white matter abnormalities were seen across multiple tracts: right cingulum-cingulate gyrus, bilateral anterior thalamic radiation, bilateral superior longitudinal fasciculus, right inferior longitudinal fasciculus, and forceps major. Results also showed modestly compromised cognitive performance and elevated intrinsic EEG activity associated with BD.

conclusionsFurther analysis indicated worse white matter integrity related to higher intrinsic EEG and modestly higher ERPs. These multimodal analyses are likely to aid in creating future informative diagnostic, etiological, and treatment targets for BD.

Indexed as

Bipolar DisorderBrainCognitionWhite MatterAdultBiomarkersDiffusion Tensor ImagingElectroencephalographyFemaleHumansMaleMiddle AgedNeuropsychological TestsYoung AdultBiomarkersbipolar disordercognitiondiffusion tensor imaging (DTI)electrophysiologyintrinsic EEG

Identifiers

PMID40084552
PMCPMC12169086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.