Evidence map›Paper›PMID 40084470›Full record

ArticleJournal of hypertension2025

Severe neurovascular hypertension in a 17-year-old girl cured by microvascular decompression.

Maximilian Middelkamp, Paula-Sophie Steffens, Valentina Vogelsang, Raphael Schild, Jens Gempt, Ania C Muntau, Lasse Dührsen

Abstract readCase Reports
In one paragraph

Article in Journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maximilian MiddelkampDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf.
Paula-Sophie SteffensUniversity Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Valentina VogelsangUniversity Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Raphael SchildUniversity Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jens GemptDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf.
Ania C MuntauUniversity Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lasse DührsenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of centrally caused hypertension in a 17-year-old adolescent due to neurovascular compression of the root entry/exit zone of the ninth/tenth cranial nerves of the rostral ventrolateral medulla oblongata on the left side. The patient underwent a comprehensive diagnostic workup to exclude other causes of secondary hypertension. A cranial magnetic resonance imaging (cMRI) indicated a neurovascular compression. The patient underwent microvascular decompression (MVD) twice. After the first MVD, blood pressure values significantly decreased to normotensive levels without any antihypertensive medication. After one year without clinical symptoms, the patient experienced recurrent hypertension and underwent a second MVD. Again, the blood pressure normalized without any medication or clinical symptoms within six-month follow-up. This case report highlights neurovascular compression at brainstem level as an important differential diagnosis of centrally caused hypertension, even in the absence of specific cranial nerve deficits. MVD is an effective treatment option.

Indexed as

HypertensionMicrovascular Decompression SurgeryAdolescentFemaleHumansMagnetic Resonance Imaging

Identifiers

PMID40084470
PMCPMC11970581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.