ArticleEndocrinology, diabetes & metabolism2025
Triglyceride-Glucose Index Association With Severity of Coronary Artery Disease.
Article in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association of Triglyceride-Glucose Index and Coronary Chronic Total Occlusion in Patients Undergoing Coronary Angiography: A Retrospective Study.Journal of cardiovascular development and disease · 2026Article
- Association of the TyG Index, Cardiometabolic Index, and Epicardial Adipose Tissue With Coronary Artery Disease.Clinical cardiology · 2026Article
- The association between triglyceride glucose-frailty index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Comparative evaluation of nine insulin resistance indices for 10-year coronary artery disease risk prediction in non-diabetic adults.Scientific reports · 2026Article
- Atherogenic Lipoprotein Burden, Metabolic Stress and Immune Activation Associated with Coronary Atherosclerosis in Patients with Psoriasis.International journal of molecular sciences · 2026Article
- Association between single-point insulin sensitivity estimator and three-vessel coronary disease: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Predictive value of insulin resistance related indicators for osteoporosis risk in patients with type 2 diabetes mellitus: a real-world study.Frontiers in molecular biosciences · 2026Article
- Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort study from the China health and retirement longitudinal study.Diabetology & metabolic syndrome · 2025Article
- Different association between triglyceride-glucose index and mild cognitive impairment in type 2 diabetes mellitus patients with and without diabetic kidney disease.Frontiers in nutrition · 2025Article
- Triglyceride glucose-body mass index is associated with diabetic kidney disease in type 2 diabetes mellitus patients without non-alcoholic fatty liver disease.Frontiers in nutrition · 2025Article
- Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundDespite previous studies, the relationship between the triglyceride-glucose (TyG) index and coronary artery disease (CAD) is still undetermined. So we aimed to investigate the association between the TyG index and CAD.
methodA total of 2346 subjects were enrolled in the study and were categorised into 5: those with no CAD, angiogram negative (Ang-) patients, those with single-vessel disease (SVD), or two-vessel disease (2VD) or three-vessel disease (3VD). Demographic characteristics, disease history and biochemical investigations were recorded. TyG index was calculated as Ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2].
resultsAdjusted regression models demonstrated that the odds of 3VD (OR, 5.847; 95% CI, 4.391-7.784), 2VD (OR, 4.943; 95% CI, 3.597-6.791), SVD (OR, 4.722; 95% CI 3.448-6.647) and a negative coronary angiogram (OR, 3.137; 95% CI, 2.431-4.049), increased significantly per each unit elevation of the TyG index, compared to the healthy participants. Also, the odds for being 3VD (1.864, 95%CI 1.402-2.477, p-value < 0.001), 2VD (1.575, 95%CI 1.143-2.171, p-value = 0.005) and SVD (1.505, 95%CI 1.097-2.065, p-value = 0.011) were increased significantly by one-unit elevation of TyG index, compared to Ang- group.
conclusionOur study demonstrates a significant association between elevated TyG index and the presence and severity of CAD. Higher TyG index values were consistently linked to an increased likelihood of multivessel CAD, especially in diabetic patients. These findings suggest that the TyG index could serve as a valuable marker for assessing CAD risk and stratification.
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