Evidence map›Paper›PMID 40084373›Full record

ArticleAmerican journal of cancer research2025

A novel gemcitabine analog as a potential anticancer agent: synthesis and

Joy Okoro, Raviteja Bulusu, Esther Frimpong, Xue Zhu, Sherise Rogers, Edward Agyare

Abstract read
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joy OkoroCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University Tallahassee, Florida, USA.
Raviteja BulusuCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University Tallahassee, Florida, USA.
Esther FrimpongCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University Tallahassee, Florida, USA.
Xue ZhuCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University Tallahassee, Florida, USA.
Sherise RogersDepartment of Medicine, Division of Hematology and Oncology, University of Florida College of Medicine Gainesville, Florida, USA.
Edward AgyareCollege of Pharmacy and Pharmaceutical Sciences, Florida A&M University Tallahassee, Florida, USA.

Funding

Tissue Modeling & Drug Development Shared Resources CoreU54CA233444 · NCI · UNIVERSITY OF FLORIDA · PI Chanita A. Hughes-Halbert, Tianze Jiao · 2018 to 2026
$12.1M
Tissue Modeling CoreU54CA233396 · NCI · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Romonia Renee REAMS · 2018 to 2026
$9.8M
NCI NIH HHS U54 CA233396NCI NIH HHS U54 CA233444
6 · The paper itself

Abstract

Gemcitabine (Gem) is approved for use in pancreatic cancer chemotherapy. However, Gem undergoes rapid metabolism in the blood, producing an inactive metabolite. Due to this rapid metabolism, the effective dose of Gem is high, thereby predisposing patients to severe adverse effects. This study aimed to improve Gem's metabolic and therapeutic stability by modifying the amine group (4-NH

Indexed as

4-N-hydroxylGem hydrochloridecytotoxicityGemcitabine analogmetabolic stabilitypancreatic cancersynthesis

Identifiers

PMID40084373
PMCPMC11897620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.