ArticleAmerican journal of cancer research2025
Efficacy of a combination of O-RADS, CEUS, and CA125, in identification of ovary-adnexal malignant lesions.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectivesTo evaluate the efficacy of a combination of Ovarian-Adnexal Reporting and Data System (O-RADS), contrast-enhanced ultrasound (CEUS), and cancer antigen 125 (CA125) in identifying malignant ovarian-adnexal lesions and improving diagnostic accuracy, providing a reliable reference for the evaluation and management of ovarian-adnexal malignancies to enhance patient prognosis.
methodsThe study analyzed the diagnostic performance of O-RADS alone and in combination with CEUS and CA125 for distinguishing between benign and malignant ovarian-adnexal lesions. Sensitivity, specificity, accuracy, and Kappa values were calculated to assess the efficacy of these diagnostic approaches.
resultsO-RADS alone showed a diagnostic sensitivity of 88.24%, specificity of 80.77%, and accuracy of 82.61% (Kappa = 0.719). When combined with CEUS, the diagnostic accuracy and Kappa value significantly improved. The combination of O-RADS, CEUS, and CA125 further enhanced the diagnostic performance, achieving sensitivity, specificity, and accuracy of 82.35%, 98.08%, and 94.20%, respectively (Kappa = 0.804).
conclusionsThe combination of O-RADS, CEUS, and CA125 significantly improves the diagnostic accuracy of ovarian-adnexal malignant lesions, providing new clinical references for the evaluation and management of ovarian-adnexal malignancies and contributing to better patient prognosis.
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