Evidence map›Paper›PMID 40084335›Full record

ArticleCureus2025

Inflammatory and Coagulation Marker Changes in PMX-DHP-Treated COVID-19 Patients.

Akinari Tsukada, Daisuke Katagiri, Shinyu Izumi, Junko Terada-Hirashima, Yosuke Shimizu, Yukari Uemura, Masaaki Toda, Taro Yasuma, Corina N D'Alessandro Gabazza, Hajime Fujimoto and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Akinari TsukadaRespiratory Medicine, National Center for Global Health and Medicine, Tokyo, JPN.
Daisuke KatagiriNephrology, National Center for Global Health and Medicine, Tokyo, JPN.
Shinyu IzumiRespiratory Medicine, National Center for Global Health and Medicine, Tokyo, JPN.
Junko Terada-HirashimaRespiratory Medicine, National Center for Global Health and Medicine, Tokyo, JPN.
Yosuke ShimizuCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JPN.
Yukari UemuraCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, JPN.
Masaaki TodaImmunology, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Taro YasumaImmunology, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Corina N D'Alessandro GabazzaImmunology, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Hajime FujimotoPulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Tetsu KobayashiPulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Esteban Cesar GabazzaImmunology, Mie University Faculty and Graduate School of Medicine, Tsu, JPN.
Masaya SugiyamaViral Pathogenesis and Controls, National Center for Global Health and Medicine, Tokyo, JPN.
Eisei NoiriNational Center Biobank Network, National Center for Global Health and Medicine, Tokyo, JPN.
Shinji AbeRespiratory Medicine, Tokyo Medical University Hospital, Tokyo, JPN.
Arata AzumaRespiratory Medicine, Nippon Medical School, Musashi Kosugi Hospital, Kawasaki, JPN.
Haruhito SugiyamaRespiratory Medicine, National Center for Global Health and Medicine, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Direct hemoperfusion using polymyxin B-immobilized polystyrene fiber column (PMX-DHP) removes endotoxin and inflammatory mediators from the blood. This study aimed to evaluate the changes in the levels of cytokines, coagulation factors, and a microbiota-derived proapoptotic peptide in COVID-19 patients treated with PMX-DHP. Methods We conducted a multicenter, prospective, single-arm interventional study of 21 oxygen-requiring patients with COVID-19 admitted between September 28, 2020, and March 31, 2022. PaO

Indexed as

coagulationcorisincoronavirus disease 2019 (covid-19)inflammatory cytokinespolymyxin b hemoperfusion

Identifiers

PMID40084335
PMCPMC11904442

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.