ArticlePeerJ2025
Propofol-based deep sedation for colonoscopy: does sufentanil, alfentanil or ketamine help? A propensity score weighted retrospective study.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis.European journal of clinical pharmacology · 2026Pooled it
- Current and Emerging Sedation Practices for Colonoscopy: A Narrative Review of Pharmacological Agents, High-Risk Populations, and Safety Considerations.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Gastrointestinal endoscopy is a frequent procedure for diagnosing and following up on various digestive disorders. It is often conducted under propofol sedation. The aim of this work is, first, to determine whether the addition of sufentanil, alfentanil, or ketamine to propofol has a propofol-sparing effect and, secondarily, how these drugs affect the patients' hemodynamic parameters and oxygenation as well as the duration of the procedure. Methods: Data from patients who underwent colonoscopy were extracted from the anesthesia records database and divided into four groups. Patients received either propofol or a combination of propofol and sufentanil, alfentanil, or ketamine. After inverse propensity weighting, we determined the average treatment effects for each group for the primary and secondary endpoints. Results: Sufentanil was associated with a less than 10% decrease in propofol consumption. Alfentanil and ketamine showed no propofol-sparing effect. Sufentanil was associated with 2 min shorter procedures. Alfentanil was associated with more patients presenting hypoxemia and had no propofol-sparing effect. Conclusion: Should a balanced sedation technique be chosen, sufentanil appears to be the adjuvant of choice, given its propofol-sparing effect and the absence of induced hypoxemia. A further prospective study is necessary to explain the lack of propofol-sparing effect of ketamine and alfentanil and confirm and explain the negative impact of alfentanil on patients' oxygenation.
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