Evidence map›Paper›PMID 40084146›Full record

ArticleFrontiers in endocrinology2025

Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China.

Yijin Wang, Qinqin Ren, Hui Yuan, Yang Wang, Yao Liu, Yuanhuan Wei, Ruifang Sun, Hongguang Yang, Ping Tian, Jianjun Yang and 1 more

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yijin WangDepartment of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Qinqin RenDepartment of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Hui YuanDepartment of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Yang WangDepartment of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Yao LiuDepartment of Clinical Nutrition, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Yuanhuan WeiDepartment of Clinical Nutrition, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Ruifang SunDepartment of Clinical Nutrition, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Hongguang YangDepartment of Clinical Nutrition, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Ping TianDepartment of Children Healthcare, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Jianjun YangDepartment of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Guifang DengDepartment of Clinical Nutrition, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have recently been reported as novel inflammatory markers of diabetes. However, the associations of SII and SIRI with the risk of gestational diabetes mellitus (GDM) are unclear. In our study, we explored the association between the SII and SIRI in early pregnancy and the risk of GDM in pregnant women. Methods: A prospective cohort of 1,505 pregnant women were recruited at 6-13 weeks of gestation in 2019 and 2020 in Shenzhen, China. SII and SIRI were determined by calculating the composite inflammation indicators from routine blood test results at 6-13 weeks of gestation, and an oral glucose tolerance test was conducted at 24-28 weeks of gestation to diagnose GDM. Logistic regression was used to analyse the correlations between the incidence of GDM and SII and SIRI. Using a restriction cubic spline with baseline SII and SIRI as continuous variables, the dose-response associations between the incidence of GDM and SII and SIRI were explored. Results: Following Ln-transformation of the SII and SIRI, multivariate models showed that Ln (SII) (odds ratio [OR] = 1.759; 95% confidence interval [CI]: 1.272-2.432) and Ln (SIRI) (OR = 1.556; 95% CI: 1.187-2.042) were positively associated with the risk of GDM in a dose-dependent manner. The OR for the highest quartile of SII compared with the lowest quartile for the risk of GDM was 2.080 (95% CI: 1.447-2.990), and the OR for the highest quartile of SIRI compared with the lowest quartile was 1.694 (95% CI: 1.170-2.452). The restricted cubic spline model confirmed a linear association between Ln (SII) and Ln (SIRI) with the risk of GDM (p-nonlinear > 0.05). Discussion: Higher SII and SIRI in early pregnancy are associated with an increased risk of GDM. As novel, valuable, and convenient indicators of inflammation, SII and SIRI could be used to a potential predictor for GDM in early pregnancy.

Indexed as

BiomarkersDiabetes, GestationalInflammationAdultChinaFemaleGlucose Tolerance TestHumansPregnancyProspective StudiesRisk FactorsBiomarkersfirst-trimestergestational diabetes mellitusinflammationpregnantprospective cohort studysystemic immune-inflammation indexsystemic inflammation response index

Identifiers

PMID40084146
PMCPMC11903260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.