Evidence map›Paper›PMID 40084077›Full record

ArticleBio-protocol2025

Isolation and Biophysical Characterization of Extracellular Vesicles from Hairy Root Cultures.

Marisa Conte, Elisa Cappetta, Mariaevelina Alfieri, Michele Bifolco, Eleonora Boccia, Mariapia Vietri, Alfredo Ambrosone

Abstract read
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In one paragraph

Article in Bio-protocol, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marisa ConteDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Elisa CappettaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Mariaevelina AlfieriDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Michele BifolcoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Eleonora BocciaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Mariapia VietriDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Alfredo AmbrosoneDepartment of Pharmacy, University of Salerno, Fisciano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membrane-bound, non-replicating particles released by virtually all types of cells. EVs concentrate and deliver a plethora of biomolecules driving very important biological functions, including intercellular communication not only between cells of the same organism but also across different kingdoms. Plant extracellular vesicles (PEVs) are a promising alternative to mammalian EVs in biomedical applications. Here, we present an optimized and reproducible protocol for isolating PEVs from the hairy root (HR) cultures of medicinal plants

Indexed as

biophysical characterizationdifferential ultracentrifugationExtracellular vesiclesHairy rootsMedicinal plantsPlant biotechnological platformsSalvia spp.

Identifiers

PMID40084077
PMCPMC11896773

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.