Evidence map›Paper›PMID 40083992›Full record

ArticleHeliyon2025

Development and characterisation of polymeric solid dispersed systems of hesperidin, obtained by centrifugal fibre formation.

Volodymyr Bessarabov, Vadym Lisovyi, Viktoriia Lyzhniuk, Viktor Kostiuk, Roman Smishko, Volodymyr Yaremenko, Andriy Goy, Tetiana Derkach, Galina Kuzmina, Svitlana Gureyeva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Volodymyr BessarabovKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Vadym LisovyiKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Viktoriia LyzhniukKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Viktor KostiukKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Roman SmishkoKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Volodymyr YaremenkoKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Andriy GoyKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Tetiana DerkachKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Galina KuzminaKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.
Svitlana GureyevaKyiv National University of Technologies and Design, 2 Mala Shyianovska Str., Kyiv, 01011, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The flavonoid hesperidin is a crucial, biologically active substance of great interest because of its polypharmacological properties and high safety profile. However, its widespread use of this bioflavonoid in remedies for the treatment and prevention of various diseases is limited by its low water solubility. This study reports on solid dispersed systems (SDSs) of hesperidin, fabricated for the first time via the method of centrifugal fibre. For one of the compositions of these SDSs, the solubility of the flavonoid in water is observed to be 150-170 times higher than that of the pure compound. Polyvinylpyrrolidones, with different molecular weights, was used as a fibre-forming polymer carrier, alongside sucrose and mannitol as auxiliary substances to enhance the yield of the composites. The SDSs of hesperidin in the form of fibres were characterised via differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR) and powder X-ray diffraction (PXRD). DSC and PXRD results confirmed the amorphisation of hesperidin in the fibrous SDSs. FTIR results confirmed that the interaction of hesperidin with the components of the SDS composites occurs due to the formation of intermolecular hydrogen bonds. Studies of in vitro release kinetics in buffer media with pH = 1.2, 4.5 and 6.8 showed that the release rate of hesperidin from the centrifugally formed SDSs is considerably higher than the dissolution rate of pure hesperidin. Thus, the results of this study confirm that centrifugal fibre formation is a simple and effective method for fabricating highly soluble SDSs of hesperidin.

Indexed as

Active pharmaceutical ingredientCentrifugal fibre formationHesperidinIncrease in solubilityPolymer carriersSolid dispersed system

Identifiers

PMID40083992
PMCPMC11904501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.