ArticleJournal of spine research and surgery2025
Lumbar Spinal Stenosis: Pathophysiology, Biomechanics, and Innovations in Diagnosis and Management.
Article in Journal of spine research and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Use of pregabalin and limaprost in the conservative treatment of lumbar spinal stenosis: a systematic review of the current evidence.European journal of clinical pharmacology · 2026Pooled it
- Efficacy of unilateral biportal endoscopy vs. unilateral portal endoscopy for the treatment of lumbar spinal stenosis: a systematic review and meta-analysis.Frontiers in surgery · 2025Pooled it
- Nonsurgical interventions for lumbar spinal stenosis with neurogenic claudication: A systematic review and network meta-analysis.Integrative medicine research · 2026Article
- MRI-defined lumbar fasciitis is associated with inferior subjective outcomes after endoscopic decompression for lumbar spinal stenosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Efficacy and Safety of the Use of Interspinous Spacers in the Treatment of Lumbar Spinal Stenosis: Mapping Gap and Scoping Review.Pain practice : the official journal of World Institute of Pain · 2026Article
- The impact of overall lumbar disc degeneration burden on disability outcomes following surgery for lumbar spinal stenosis due to osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Effect of vosoritide on spine morphology in children with achondroplasia: 1-year results from a randomized phase 2 study.Journal of the Endocrine Society · 2026Article
- Clinical outcomes of uni-portal non-coaxial spinal endoscopic surgery versus unilateral biportal endoscopic surgery for lumbar spinal stenosis: a retrospective cohort study.Frontiers in surgery · 2026Article
- Outcomes and safety of unilateral biportal endoscopy for lumbar spinal stenosis.American journal of translational research · 2026Article
- Integrating Mechanical Diagnosis and Therapy Within Multidisciplinary Biopsychosocial Care for Chronic Musculoskeletal Pain.Journal of orthopaedics and sports medicine · 2026Article
- Lumbar spinal stenosis exacerbated by spinal epidural lipomatosis: a case report.Frontiers in surgery · 2026Article
- Central Canal Stenosis Severity Does Not Predict Residual Leg Pain After Percutaneous Transforaminal Endoscopic Decompression in Frail Elderly Patients: A Propensity Score-Weighted Cohort Study.Journal of pain research · 2026Article
- Targeting transthyretin deposition in lumbar spinal stenosis: a mechanistic rationale for tafamidis.Frontiers in surgery · 2026Article
- Perioperative Anxiety and Stress Cortisol on Postoperative Pain: Pharmacological and Non-Pharmacological Management Strategies.Journal of surgery and research · 2026Article
- Postoperative Recovery of Balance Function in Lumbar Spinal Stenosis: A 12-Month Longitudinal Study Using the Brief BESTest and Its Association with Patient-Reported Outcomes.Journal of clinical medicine · 2025Article
- Temporary Relative Lumbar Spinal Stenosis After Skip Partial Laminectomies in an Elderly Woman: A Case Report.Cureus · 2025Article
- Long-Term Outcomes of Minimally Invasive vs. Traditional Open Spinal Fusion: A Comparative Analysis.Journal of spine research and surgery · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Lumbar spinal stenosis (LSS) is a common condition caused by the narrowing of the spinal canal, resulting in compression of neural and vascular structures. This compression leads to symptoms such as claudication, paresthesia, and lower extremity weakness. LSS is the leading cause of low back pain and functional limitations, affecting over 103 million people worldwide. Degenerative changes, including ligamentum flavum hypertrophy, facet joint osteoarthritis, and intervertebral disc degeneration, are the primary contributors to LSS. Additional factors, such as genetic predisposition, congenital abnormalities, and autoimmune conditions, are also emerging as contributors. A major challenge in managing LSS lies in differentiating it from other causes of neurogenic symptoms and low back pain while devising an appropriate treatment plan from the wide array of conservative and surgical options available. Minimally invasive surgical techniques, such as lumbar spinous process-splitting laminoplasty and partial facetectomy, are often compared to the gold standard laminectomy with or without fusion. Surgical interventions offer significant improvements in pain relief, disability, and quality of life within 3-6 months; however, these benefits often diminish after 2-4 years. Contrasting evidence demonstrates that long-term outcomes of non-surgical treatments, such as physical therapy, pharmacological management, and lifestyle modifications, are often comparable to surgical modalities. Emerging therapies, including interspinous devices and stem cell therapy, show promise but require further research. Managing LSS requires a multidisciplinary approach tailored to patient-specific factors, including age, comorbidities, and functional goals. Future research should aim to improve diagnostic accuracy, refine surgical techniques, and explore innovative therapies to enhance outcomes for patients with LSS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.