Evidence map›Paper›PMID 40083958›Full record

ArticleAddiction neuroscience2025

Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review.

Laya Jalilian-Khave, Razi Kitaneh, Binah Baht Ysrayl, Anna Borelli, Melissa C Funaro, Marc N Potenza, Gustavo A Angarita

Abstract read
In one paragraph

Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The relationship between smoking cessation and vitamin D.Irish journal of medical science · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laya Jalilian-KhaveDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Razi KitanehDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Binah Baht YsraylDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Anna BorelliDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Melissa C FunaroHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT, USA.
Marc N PotenzaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Gustavo A AngaritaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.

Funding

Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Vitamin D Modulation of Midbrain Dopamine Function: A 11C-PHNO PET Study in Healthy HumansR01AT010508 · NCCIH · YALE UNIVERSITY · PI POTENZA, MARC N · 2019 to 2020
$1.7M
NCCIH NIH HHS R01 AT010508NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. We searched Ovid MEDLINE, Embase, APA PsycInfo, Cochrane Library, Web of Science, and Scopus databases. We extracted and summarized quantitative and qualitative data through a narrative synthesis and assessed the quality of studies using the Joanna Briggs Institute (JBI) and SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation) criteria. Of 5,442 initial records identified, 28 preclinical and clinical studies were included. For most conditions, we found a negative relationship between vitamin D levels and symptom presence and/or severity. While data suggest a potential beneficial effect of vitamin D on preventing or treating these conditions, there were significant limitations identified by the JBI and SYRCLE assessments. Future studies should include impulse control disorders and other under-explored conditions, address heterogeneity regarding forms, doses, and duration of exposures to vitamin D, and explore vitamin D's potential therapeutic mechanisms.

Indexed as

Addictive behaviorsCompulsive behaviorsDopaminergic neurotransmissionImpulsive behaviorsSubstance use disordersVitamin D

Identifiers

PMID40083958
PMCPMC11902922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.