Evidence map›Paper›PMID 40083955›Full record

ArticleClinical kidney journal2025

Vitamin D: are all compounds equal?

Lorenza Magagnoli, Matthias Cassia, Andrea Galassi, Paola Ciceri, Elisabet Massó, Rosana Gelpi, Jordi Bover, Mario Cozzolino

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorenza MagagnoliDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0003-2853-1332
Matthias CassiaNephrology Unit, Spedali Civili di Brescia Hospital, ASST Spedali Civili di Brescia, Brescia, Italy.
Andrea GalassiRenal and Dialysis Unit, ASST Rhodense, Garbagnate, Milan, Italy.
Paola CiceriLaboratory of Experimental Nephrology, Department of Health Sciences, University of Milan, Milan, Italy.
Elisabet MassóNephrology Department, University Hospital Germans Trias I Pujol, REMAR-IGTP Group, RICORS 2040 Network, Barcelona, Spain.
Rosana GelpiNephrology Department, University Hospital Germans Trias I Pujol, REMAR-IGTP Group, RICORS 2040 Network, Barcelona, Spain.
Jordi BoverNephrology Department, University Hospital Germans Trias I Pujol, REMAR-IGTP Group, RICORS 2040 Network, Barcelona, Spain.
Mario CozzolinoDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-8494-6252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is a pre-hormone essential for maintaining mineral homeostasis and also plays significant roles in bone, cardiovascular and renal health. Vitamin D deficiency is prevalent in the general population, and even more so in chronic kidney disease (CKD) patients, in which it contributes to the development and progression of mineral and bone disorder. The landscape of vitamin D treatment has evolved, with several analogues now available, each possessing distinct pharmacokinetic and pharmacodynamic properties, efficacies and safety profiles. This diversity allows for tailored, personalized approaches to treatment in CKD patients. This review aims to provide a comprehensive overview of vitamin D, including its natural sources and metabolism, and examines the main available pharmacological vitamin D products. Particular emphasis is placed on their application in CKD management, highlighting how these compounds can be strategically used to address both vitamin D deficiency and secondary hyperparathyroidism, while also acknowledging the ongoing debate about their impact on bone health and other clinical outcomes.

Indexed as

calcifediolCKDsecondary hyperparathyroidismVDRAvitamin D

Identifiers

PMID40083955
PMCPMC11903094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.