Evidence map›Paper›PMID 40083918›Full record

ArticleTheranostics2025

Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1.

Xueying Wang, Diekuo Zhang, Jiaqing Xiao, Lei Wang, Junrong Wang, Xiaoqiao Cui, Jiaqi Tan, Yong Liu, Susheng Miao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xueying WangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan, The People's Republic of China.
Diekuo ZhangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan, The People's Republic of China.
Jiaqing XiaoInstitute of Heilongjiang Province Center for Disease Control Disinfection and Infection, Harbin 150081, Heilongjiang, The People's Republic of China.
Lei WangDepartment of Otorhinolaryngology Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang, The People's Republic of China.
Junrong WangDepartment of Otorhinolaryngology Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang, The People's Republic of China.
Xiaoqiao CuiDepartment of Otorhinolaryngology Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang, The People's Republic of China.
Jiaqi TanDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan, The People's Republic of China.
Yong LiuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan, The People's Republic of China.
Susheng MiaoDepartment of Otorhinolaryngology Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang, The People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immune Checkpoint InhibitorsLysosomal-Associated Membrane Protein 2LysosomesMembrane ProteinsProgrammed Cell Death 1 ReceptorProtein Serine-Threonine KinasesAnimalsAntibodies, MonoclonalCD8-Positive T-LymphocytesCell Line, TumorChaperone-Mediated AutophagyFemaleHumansMiceSTING ProteinAntibodies, MonoclonalImmune Checkpoint InhibitorsLAMP2 protein, humanLysosomal-Associated Membrane Protein 2Membrane ProteinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorProtein Serine-Threonine KinasesSTING1 protein, humanSTING ProteinTBK1 protein, humanCMALAMP2APD-1STINGTBK1

Identifiers

PMID40083918
PMCPMC11898276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.