Evidence map›Paper›PMID 40083862›Full record

ReviewMolecular and clinical oncology2025

Exploring the complex relationship between metabolomics and breast cancer early detection (Review).

Omar Mahmoud Alshajrawi, Tengku Ahmad Damitri Al Astani Tengku Din Tengku Din, Shahira Sofea Binti Marzuki, Maulidiani Maulidiani, Nurul Anaqi Rukaini Binti Mohd Rusli, Norul Faezzatul Ain Binti Badrol Hisham, Lim Hui Ying, Maya Mazuwin Binti Yahya, Wan Norlina Binti Wan Azman, Ras A Ramli and 1 more

Abstract readReview
In one paragraph

Review in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Omar Mahmoud AlshajrawiDepartment of Chemical Pathology, School of Medical Science, Health Campus, University Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Tengku Ahmad Damitri Al Astani Tengku Din Tengku DinDepartment of Chemical Pathology, School of Medical Science, Health Campus, University Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Shahira Sofea Binti MarzukiDepartment of Chemical Pathology, School of Medical Science, Health Campus, University Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Maulidiani MaulidianiFaculty of Science and Marine Environment, University Malaysia Terengganu, Kuala Nerus, Terengganu 21030, Malaysia.
Nurul Anaqi Rukaini Binti Mohd RusliFaculty of Science and Marine Environment, University Malaysia Terengganu, Kuala Nerus, Terengganu 21030, Malaysia.
Norul Faezzatul Ain Binti Badrol HishamFaculty of Science and Marine Environment, University Malaysia Terengganu, Kuala Nerus, Terengganu 21030, Malaysia.
Lim Hui YingFaculty of Science and Marine Environment, University Malaysia Terengganu, Kuala Nerus, Terengganu 21030, Malaysia.
Maya Mazuwin Binti YahyaDepartment of Surgery, School of Medical Science, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Wan Norlina Binti Wan AzmanDepartment of Chemical Pathology, School of Medical Science, Health Campus, University Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Ras A RamliFaculty of Medicine, University Sultan Zainal Abidin, Kuala Terengganu, Terengganu 20400, Malaysia.
Wan Faiziah Wan Abdul RahmanDepartment of Pathology, School of Medical Science, Health Campus, University Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An overview of metabolomics in cancer research, focusing on the identification of biomarkers, pharmacological targets and therapeutic agents, is provided in the present review. The fundamentals of metabolomics, the role of metabolites in cancer emergence and the methods used in metabolomic analysis, are reviewed. The applications of metabolomics in cancer therapy and diagnostics, as well as the challenges encountered in metabolomic research, are discussed. Finally, the potential clinical uses of metabolomics in cancer research and its future possibilities are explored, emphasising the importance of non-invasive diagnostic and monitoring techniques. The present review highlights the significance of metabolite-based metabolomics as a specialised tool for illuminating disease processes and identifying treatment potentials. The malfunctioning of metabolomic pathways and metabolite accumulation or depletion is caused by metabolomics abnormalities. Metabolite signatures close to a subject's phenotypic informative dimension can be used to monitor therapies and disease prediction diagnosis and prognosis. Non-invasive diagnostic and monitoring techniques with high specificity and selectivity are urgently needed. Metabolite-based metabolomics is a specialised metabolic biomarker and pathway-analysis technique, illuminating the putative processes of numerous human illnesses and determining treatment potentials. Locating biochemical pathway modifications that are early warning signs of pathological malfunction and illness is possible by identifying functional biomarkers linked to phenotypic variance. Scientists generated numerous metabolomics profiles to disclose the underlying processes and metabolomics networks for therapeutic target research in biomedicine. The metabolomic analysis of the potential utility of metabolites as biomarkers for clinical events is summarised in the present review. The significance of metabolite-based metabolomics as a specialised tool for illuminating disease processes and identifying treatment potentials is highlighted.

Indexed as

breast cancerdiagnosticmetabolitesmetabolomicspathway

Identifiers

PMID40083862
PMCPMC11905217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.