ReviewTransplant international : official journal of the European Society for Organ Transplantation2025
Contributions of Europeans to Xenotransplantation Research: 1. Pig Organ Xenotransplantation.
Review in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Lung transplantation in 2025: a narrative review of progress, challenges, and the road ahead.Journal of thoracic disease · 2026Review
- Xenotransplantation and the organ shortage: evaluating policy priorities.Current opinion in organ transplantation · 2026Review
- Developing European policy on xenotransplantation: instructive findings from the first representative UK sample survey on attitudes and views on animal to human transplants.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals.Current issues in molecular biology · 2025Review
- Immunosuppressive and Non-Immunosuppressive Drugs for Heart Xenotransplantation in Humans: Is Europe Ready?XenotransplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Xenotransplantation has a rich history, marked by European pioneers who laid the groundwork for many breakthroughs in the field. Pig organ xenotransplantation offers a solution to the global shortage of deceased human donor organs, whilst allowing the modification of the donor graft itself. The field has continued to garner interest, particularly with the recent advent of simpler and faster genetic-engineering technologies. This review highlights the contributions of European researchers to xenotransplantation, spanning pig kidney, heart, liver, and lung transplantation. Research has focused on (i) identifying and deleting key xenoantigens and modifying the source pig by expression of human "protective" proteins and (ii) testing novel immunosuppressive regimens. These contributions have played key roles in advancing xenotransplantation from the laboratory to early clinical experiments. Europeans have also addressed the potential risks of xenozoonotic infections and the regulatory challenges. The research endeavours of groups in Europe are summarized. Several European researchers moved either permanently or temporarily to US institutions, and their insight and innovations are also highlighted. While we aim to recognize the significant contributions of European physicians and scientists in this article, it is not an exhaustive list of all those who have influenced the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.