Evidence map›Paper›PMID 40083774›Full record

ArticleBioactive materials2025

In situ UNIversal Orthogonal Network (UNION) bioink deposition for direct delivery of corneal stromal stem cells to corneal wounds.

Lucia G Brunel, Betty Cai, Sarah M Hull, Uiyoung Han, Thitima Wungcharoen, Gabriella Maria Fernandes-Cunha, Youngyoon Amy Seo, Patrik K Johansson, Sarah C Heilshorn, David Myung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lucia G BrunelDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Betty CaiDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Sarah M HullDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Uiyoung HanDepartment of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Thitima WungcharoenDepartment of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Gabriella Maria Fernandes-CunhaDepartment of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Youngyoon Amy SeoDepartment of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Patrik K JohanssonDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Sarah C HeilshornDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
David MyungDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.

Funding

3D bioprinting of a bilayered, tissue engineered corneaR01EY035697 · NEI · STANFORD UNIVERSITY · PI Sarah C Heilshorn, David Myung · 2024 to 2026
$1.6M
NEI NIH HHS R01 EY035697
6 · The paper itself

Abstract

The scarcity of human donor corneal graft tissue worldwide available for corneal transplantation necessitates the development of alternative therapeutic strategies for treating patients with corneal blindness. Corneal stromal stem cells (CSSCs) have the potential to address this global shortage by allowing a single donor cornea to treat multiple patients. To directly deliver CSSCs to corneal defects within an engineered biomatrix, we developed a UNIversal Orthogonal Network (UNION) collagen bioink that crosslinks

Indexed as

BiomaterialCollagen bioinkCollagen crosslinkingCorneal regenerationCorneal stromal stem cellHydrogel cell carrier

Identifiers

PMID40083774
PMCPMC11903395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.