Evidence map›Paper›PMID 40083717›Full record

ArticleiScience2025

Temporal-coherence induces binding of responses to sound sequences in ferret auditory cortex.

Kai Lu, Kelsey Dutta, Ali Mohammed, Mounya Elhilali, Shihab Shamma

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. A perceptual grouping model for auditory kappa effects.Journal of experimental psychology. Human perception and performance · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kai LuDepartment of Biology, Emory University, Atlanta, GA, USA.
Kelsey DuttaElectrical and Computer Engineering Department & Institute for Systems Research, University of Maryland, College Park, MD, USA.
Ali MohammedElectrical and Computer Engineering Department & Institute for Systems Research, University of Maryland, College Park, MD, USA.
Mounya ElhilaliElectrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Shihab ShammaElectrical and Computer Engineering Department & Institute for Systems Research, University of Maryland, College Park, MD, USA.

Funding

Speech Perception with High Cognitive DemandP01AG055365 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI GORDON-SALANT, SANDRA M · 2017 to 2021
$8.4M
Spectro-Temporal Plasticity in Primary Auditory CortexR01DC005779 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI Shihab A Shamma · 2004 to 2026
$6.7M
Neural Correlates of Streaming of Complex SoundsR01DC007657 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI SHAMMA, SHIHAB A · 2006 to 2015
$3.8M
Neural Correlates of Streaming of Complex SoundsR01DC016119 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI SHAMMA, SHIHAB A · 2018 to 2022
$2.9M
NIA NIH HHS P01 AG055365NIDCD NIH HHS R01 DC005779NIDCD NIH HHS R01 DC007657NIDCD NIH HHS R01 DC016119
6 · The paper itself

Abstract

Binding the attributes of a sensory source is necessary to perceive it as a unified entity within its surrounding scene as in the cocktail party problem in auditory perception. It is postulated that coherent temporal modulation of a source's features binds them and enhances their perception. This study seeks evidence for rapid binding among coherently responsive single-neurons in ferret auditory cortex. In one experiment, ferrets attended to a sequence of noise bursts while we contrasted responses to simultaneous synchronized versus alternating tone sequences. We found that the contrast between synchronized (enhanced) and desynchronized (suppressed) responses rapidly increased, thus promoting their segregation. In another experiment, a sequence of an irregularly repeated multi-tone complex was embedded in a background of randomly dispersed tones. Single-unit and functional ultrasound imaging of responses to the temporally coherent tones of the complex became rapidly enhanced against the background responses, demonstrating the role of temporal-coherence in binding and segregation.

Indexed as

Behavioral neuroscienceSensory neuroscience

Identifiers

PMID40083717
PMCPMC11903941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.