Evidence map›Paper›PMID 40083716›Full record

ArticleiScience2025

KAT6B overexpression in mice causes aggression, anxiety, and epilepsy.

Maria I Bergamasco, Ezgi Ozturk, Pablo M Casillas-Espinosa, Alexandra L Garnham, Waruni Abeysekera, Verena C Wimmer, Pradeep Rajasekhar, Hannah K Vanyai, Lachlan Whitehead, Marnie E Blewitt and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maria I BergamascoThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Ezgi OzturkDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville VIC 3052, Australia.
Pablo M Casillas-EspinosaDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville VIC 3052, Australia.
Alexandra L GarnhamThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Waruni AbeysekeraThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Verena C WimmerThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Pradeep RajasekharThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Hannah K VanyaiThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Lachlan WhiteheadThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Marnie E BlewittThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Kelly RogersThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Adam P VogelCentre for Neurosciences of Speech, The University of Melbourne, Melbourne, VIC 3052, Australia.
Anthony J HannanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Gordon K SmythThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Nigel C JonesDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville VIC 3052, Australia.
Tim ThomasThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of the gene encoding the histone acetyltransferase KAT6B (MYST4/MORF/QKF) causes developmental brain abnormalities as well as behavioral and cognitive defects in mice. In humans, heterozygous variants in the

Indexed as

Behavioral neuroscienceBiological sciencesMolecular neuroscienceNeuroscience

Identifiers

PMID40083716
PMCPMC11904597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.