Evidence map›Paper›PMID 40083713›Full record

ArticleJournal of medical diagnostic methods2024

A Point-of-Care Diagnostic Platform for Detecting Host Immune Activation due to Infections: Cytocapture of Biomarkers

Timothy A McCaffrey, Richard Wargowsky, Kevin Jaatinen, Faisal Al Munajjed, Farris Alqalam, John Perkins, Zane Hayden, Mary Pasquale, Grace Holloway, Jennifer Goldman and 11 more

Abstract read
In one paragraph

Article in Journal of medical diagnostic methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Timothy A McCaffreyDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Richard WargowskyDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Kevin JaatinenDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Faisal Al MunajjedDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Farris AlqalamDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
John PerkinsDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Zane HaydenDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Mary PasqualeDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Grace HollowayDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Jennifer GoldmanDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Zachary FalkDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Tisha JepsonDepartment of Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
David YamaneDepartment Anesthesiology and Critical Care Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
John LaFleurDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Andrew MeltzerDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Soroush ShahamatdarDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Ryan HeidishDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Eduard ShaykhinurovDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Aditya LoganathanDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Tarun LoganathanDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.
Taylor BoldenDepartment of Emergency Medicine, The George Washington University Medical Center, Washington, DC, United States of America.

Funding

Acquisition of the BioRad QX200 AutoDG Droplet Digital PCR SystemS10OD021622 · OD · GEORGE WASHINGTON UNIVERSITY · PI JONES, R. BRAD · 2016 to 2016
$125k
NIH HHS S10 OD021622
6 · The paper itself

Abstract

The prompt diagnosis of internal infections is an important, but surprisingly difficult, component of healthcare. Existing clinical and laboratory tests, such as complete blood counts, are low accuracy (~70%), time consuming (>90 min), and require expensive blood analyzers. More sensitive and specific tests, such as PCR or sequencing, require access to a sample of the infected tissue, genomic data for all potential pathogens and expensive equipment. Culturing organisms introduces its own biases and is prone to false positives due to contamination. We describe a device for the rapid isolation of neutrophils and measurement of neutrophil elastase activity to provide a measure of host immune activity toward a broad range of infectious agents. CyBIS (Cytocapture of Biomarkers

Indexed as

CD15CD66bCOVID-19ElastaseInfectionNeutrophilPoint of careSepsis

Identifiers

PMID40083713
PMCPMC11905667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.