Evidence map›Paper›PMID 40083698›Full record

ArticleInternational journal of biological sciences2025

Mitochondrial Localization and Function of Adenosine Receptors.

Alejandro Sánchez-Melgar, Valentina Vultaggio-Poma, Simoneta Falzoni, Clara Fructuoso, José Luis Albasanz, Francesco Di Virgilio, Mairena Martín

Abstract read
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alejandro Sánchez-MelgarDepartment of Inorganic, Organic Chemistry and Biochemistry. Faculty of Medicine of Ciudad Real / Faculty of Chemical Sciences and Technologies. Institute of Biomedicine (IB-UCLM). IDISCAM. University of Castilla-La Mancha. Ciudad Real, Spain.
Valentina Vultaggio-PomaDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Simoneta FalzoniDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Clara FructuosoDepartment of Inorganic, Organic Chemistry and Biochemistry. Faculty of Medicine of Ciudad Real / Faculty of Chemical Sciences and Technologies. Institute of Biomedicine (IB-UCLM). IDISCAM. University of Castilla-La Mancha. Ciudad Real, Spain.
José Luis AlbasanzDepartment of Inorganic, Organic Chemistry and Biochemistry. Faculty of Medicine of Ciudad Real / Faculty of Chemical Sciences and Technologies. Institute of Biomedicine (IB-UCLM). IDISCAM. University of Castilla-La Mancha. Ciudad Real, Spain.
Francesco Di VirgilioDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Mairena MartínDepartment of Inorganic, Organic Chemistry and Biochemistry. Faculty of Medicine of Ciudad Real / Faculty of Chemical Sciences and Technologies. Institute of Biomedicine (IB-UCLM). IDISCAM. University of Castilla-La Mancha. Ciudad Real, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-protein coupled receptors (GPCRs) are typically expressed on the cell surface where they mediate extracellular signals from hormones, neurotransmitters and growth factors, among others. However, growing evidence support the intracellular localization of GPCRs, including mitochondria. In the present work, we assessed the presence and functionality of adenosine receptors in mitochondria by combining techniques such as western blotting, radioligand binding, electron microscopy, enzymatic activities determination, oxygen consumption measurement and 3D morphological analysis of mitochondrial networks. Our results demonstrate the mitochondrial localization of adenosine A

Indexed as

MitochondriaReceptors, Purinergic P1Adenosine TriphosphateAminopyridinesAnimalsBlotting, WesternBrainHeLa CellsHumansMiceAdenosine TriphosphateAminopyridinesBAY 60-6583Receptors, Purinergic P1adenosine receptorsATP productionintracellular GPCRmitochondrial morphology

Identifiers

PMID40083698
PMCPMC11900819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.