Evidence map›Paper›PMID 40083697›Full record

ArticleInternational journal of biological sciences2025

eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.

Lifen Zhang, Lu Wang, Ziyao Xu, Xingmei Zhang, Shaoyu Guan, Zhe Liu, Shanzhi Gu, Lin Zhao, Weichao Bai, Tian Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lifen ZhangDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Lu WangDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Ziyao XuSenior Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Xingmei ZhangCollege of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China.
Shaoyu GuanPharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Centre of PLA General Hospital, Beijing 100853, China.
Zhe LiuDepartment of Pancreatic-Biliary Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
Shanzhi GuDepartment of Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Lin ZhaoDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Weichao BaiDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Tian LiTianjin Key Laboratory of Acute Abdomen Disease-Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine of Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China.
Xinhan ZhaoDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intricate relationship between tumor-associated macrophages (TAMs) and cancer cells is pivotal for carcinogenesis, with TAMs being integral to the tumor microenvironment (TME). This study explores the novel mechanisms by which TAMs regulate the progression of triple-negative breast cancer (TNBC) within the TME. Using a co-culture system and methodologies such as cytokine arrays, proteomics, and CRISPR-Cas9, we investigated the crosstalk between TAMs and TNBC cells. We found that high levels of CD163

Indexed as

CytokinesNeoplastic Stem CellsSTAT3 Transcription FactorTriple Negative Breast NeoplasmsTumor-Associated MacrophagesCell Line, TumorCell MovementFemaleHumansMacrophagesTumor MicroenvironmentCytokinesSTAT3 protein, humanSTAT3 Transcription FactorCancer stemnessExtracellular nicotinamide phosphoribosyltransferaseMetastasisTriple-negative breast cancerTumor-associated macrophages

Identifiers

PMID40083697
PMCPMC11900821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.