ArticleJournal of thoracic disease2025
Association of sarcopenia with basic activities of daily living and dyspnea-related limitations in patients with interstitial lung disease.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sarcopenia is characterized by loss of muscle mass and function and is known to impair activities of daily living (ADL) in community-dwelling elderly people. However, the impact of sarcopenia on ADL in patients with interstitial lung disease (ILD) remains unclear. This study aimed to determine the relationship between sarcopenia and ADL in ILD patients and to identify sarcopenia components that contribute to these impairments. Methods: This cross-sectional study included 50 patients (median age 76 years) with stable ILD who were hospitalized at Hyogo Medical University Hospital between June 2022 and February 2024. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. Basic ADL were evaluated using the Barthel Index (BI), and the impact of dyspnea on ADL was assessed using the Barthel Index-dyspnea (BI-d). Clinical assessments included the 6-min walk test, the Hospital Anxiety and Depression Scale score, and the EuroQol-5 Dimensions-5 Levels tool. Statistical analyses were performed to compare outcomes between patients with and without sarcopenia and to identify factors affecting BI and BI-d scores. Results: Sarcopenia was diagnosed in 21 patients (42%). The BI score was significantly lower (85 Conclusions: Sarcopenia was significantly associated with greater impairment of basic ADL and limitation of ADL by dyspnea in patients with ILD. SMI and gait speed are components of sarcopenia that affect these outcomes. Targeted interventions are needed to improve ADL and quality of life in these patients.
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