ArticleJournal of thoracic disease2025
Two versus three to four cycles of neoadjuvant immunochemotherapy for stage IB-IIIB non-small cell lung cancer: a real-world study.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Neoadjuvant immunochemotherapy vs. neoadjuvant targeted therapy plus chemotherapy for EGFR-mutated non-small cell lung cancer: a retrospective study.BMC cancer · 2026Article
- Comparison of the short-term efficacy and safety of surgical operation of neoadjuvant sintilimab and camrelizumab, both in combination with chemotherapy in the treatment of resectable non-small cell lung cancer: a single-center retrospective cohort study.Journal of thoracic disease · 2025Article
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9 authors.
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Abstract
Background: No consensus exists regarding the optimal number of cycles of neoadjuvant immunochemotherapy for patients with stage IB-IIIB non-small cell lung cancer (NSCLC). In this study, we compared the efficacy and safety of 2 cycles of neoadjuvant immunochemotherapy in stage IB-IIIB NSCLC with those of 3-4 cycles. Methods: All patients with IB-IIIB NSCLC who received preoperative immunochemotherapy at the Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, from 2019 to 2022 were consecutively included in this retrospective study. Subsequently, 1:1 propensity score matching (PSM) according to baseline characteristics was performed to compare the efficacy and safety between the 2-cycle group and the 3 to 4-cycle group. The follow-up period was required to be at least 1 year after surgery or when the patient decided to abandon treatment. Results: Of the 184 patients with stage IB-IIIB NSCLC included in the analysis, 61 received 2 cycles of neoadjuvant immunochemotherapy while 123 received 3-4 cycles. After a 1:1 PSM, there were no significant differences in baseline clinicopathological characteristics among the108 patients (54 pairs) who received 2 cycles or 3-4 cycles of neoadjuvant immunochemotherapy. The objective response rate (ORR) in the 3 to 4-cycle group was significantly higher than that in the 2-cycle group (83.3% Conclusions: Three to four cycles of neoadjuvant immunochemotherapy can result in more tumor regression in IB-IIIB NSCLC. Extending the number of cycles to 3-4 cycles may be feasible and safe in IB-IIIB NSCLC.
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