ArticleAmerican journal of ophthalmology case reports2025
Spectral-domain optical coherence tomography imaging findings in patients receiving teprotumumab for thyroid eye disease.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Prior studies have demonstrated the potential side effects of insulin-like growth factor-1 (IGF-1) inhibition for thyroid eye disease (TED) including hearing loss. In this study, we assessed changes in functional vision including visual field testing and best-corrected visual acuity (BCVA), clinical examination parameters, and spectral-domain optical coherence tomography (SD-OCT) biomarkers in patients who received insulin growth factor receptor-1 (IGF-R1) inhibition with teprotumumab for TED. Design: Retrospective, noncomparative cohort. Subjects: 22 eyes of 12 TED patients. Methods and outcomes measures: Retrospective chart review was conducted, with demographics, clinical examination, BCVA, Humphrey visual field (HVF), and SD-OCT data: central foveal thickness (CFT), sub-foveal choroidal thickness (SFCT), choroidal vascular index (CVI), retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (mGCIPL) thickness compared between before and after an 8-infusion course of teprotumumab. Linear regression modeling with clustering was used for statistical analysis. Statistical significance was set at p < 0.05. Results: Proptosis, clinical activity scores, and intraocular pressure improved. SFCT -35.7μm (p = 0.038), RNFL -5.41μm (p = 0.001), and mGCIPL -7.35μm (p = 0.010) decreased after six months. CFT and CVI did not statistically differ. BCVA and HVF mean deviation remained stable. Conclusions: There were statistically significant decreases in SFCT, RNFL, and mGCIPL in TED patients treated with teprotumumab, but no differences in CFT and CVI. Functional testing, with HVF and BCVA, was not affected, but there were significant systemic side effects including hearing loss noted in several patients. Further research is needed to understand the potential effects of IGF-1R blockade on the retina and optic nerve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.