Evidence map›Paper›PMID 40083348›Full record

ReviewCurrent research in insect science2025

A model that integrates the different piRNA biogenesis pathways based on studies in silkworm

Thomas-Wolf Verdonckt, Luc Swevers, Dulce Santos

Abstract readReview
In one paragraph

Review in Current research in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas-Wolf VerdoncktMolecular Developmental Physiology and Signal Transduction Research Group, Animal Physiology and Neurobiology Division, Department of Biology, KU Leuven, Naamsestraat 59 box 2465, 3000 Leuven, Belgium.
Luc SweversInsect Molecular Genetics and Biotechnology, Institute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", Aghia Paraskevi, 15341 Athens, Greece.
Dulce SantosMolecular Developmental Physiology and Signal Transduction Research Group, Animal Physiology and Neurobiology Division, Department of Biology, KU Leuven, Naamsestraat 59 box 2465, 3000 Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIWI-interacting (pi) RNAs play an essential role in protecting the genomic integrity of germ cells from the disruptive transpositions of selfish genetic elements. One of the most important model systems for studying piRNA biogenesis is the ovary derived BmN4 cell line of the silkworm Bombyx mori. In recent years, many steps and components of the pathways involved in this process have been unraveled. However, a holistic description of piRNA biogenesis in BmN4 cells is still unavailable. In this paper, we review the state of the art and propose a novel model for piRNA biogenesis in BmN4 cells. This model was built considering the latest published data and will empower researchers to plan future experiments and interpret experimental results.

Indexed as

Bombyx moriImmunitypiRNA biogenesisRNA interferenceTransposons

Identifiers

PMID40083348
PMCPMC11904557

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.