Evidence map›Paper›PMID 40083193›Full record

ArticleInternational journal of stroke : official journal of the International Stroke Society2025

Impact of atrial fibrillation on outcomes in stroke patients with tandem occlusions treated with thrombectomy: A multicentre study.

Lucio D'Anna, Matteo Foschi, Mariarosaria Valente, Liqun Zhang, Nina Mansoor, Matthew Fallon, Adelaida Gartner Jaramillo, Fedra Kuris, Antonio Taglialatela, Francesco Toraldo and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stroke : official journal of the International Stroke Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lucio D'AnnaDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.ORCID 0000-0002-4349-3322
Matteo FoschiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-0321-7155
Mariarosaria ValenteClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.
Liqun ZhangDepartment of Neuroscience, City St George's, University of London, London, UK.
Nina MansoorDepartment of Neuroscience, City St George's, University of London, London, UK.
Matthew FallonDepartment of Neuroscience, City St George's, University of London, London, UK.
Adelaida Gartner JaramilloDepartment of Neuroscience, City St George's, University of London, London, UK.
Fedra KurisClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.
Antonio TaglialatelaClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.
Francesco ToraldoClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.
Filippo KomauliClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.ORCID 0009-0001-6686-2696
Massimo SponzaNeuroradiology, Udine University Hospital, Udine, Italy.
Vladimir GavrilovicVascular and Interventional Radiology, Udine University Hospital, Udine, Italy.
Kyriakos LobotesisNeuroradiology, Department of Imaging, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.ORCID 0000-0001-5093-9751
Gian Luigi GigliClinical Neurology, Department of Medicine, Udine University Hospital, University of Udine, Udine, Italy.
Soma BanerjeeDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.
Giovanni MerlinoStroke Unit, Udine University Hospital, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTandem occlusions, involving simultaneous extracranial and intracranial artery blockages, represent a complex subtype of acute ischemic stroke treated with mechanical thrombectomy (MT). However, to date, the impact of atrial fibrillation (AF) on outcomes in this population remains unclear. This study aimed to evaluate the safety and efficacy of MT in patients with tandem occlusions, comparing those with AF to their counterparts without AF.

methodsWe performed a multicentre, retrospective study using inverse probability weighting (IPW) to evaluate the effect of AF on outcomes in tandem occlusion patients treated with MT across three comprehensive stroke centers. The primary outcome was functional independence at 90 days (modified Rankin Scale [mRS] 0-2). Secondary outcomes included recanalization success (Treatment in Cerebral Infarction (TICI) ⩾ 2b), intracranial hemorrhage (ICH), symptomatic ICH (sICH), and 90-day mortality. Subgroup analyses assessed the interaction between AF and clinical or procedural factors.

resultsAmong 635 patients, 164 (25.8%) had AF (Tandem

conclusionsPatients with tandem occlusion and AF undergoing MT showed significantly worse functional and survival outcomes relative to their non-AF counterparts, despite comparable procedural success rates. These findings highlight the critical need for tailored management strategies to mitigate the unique risks associated with AF in this population. Further research is essential to refine therapeutic approaches and improve outcomes for this high-risk group.

Indexed as

Atrial FibrillationIschemic StrokeStrokeThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcomeacute ischemic strokeatrial fibrillationmechanical thrombectomytandemTandem occlusion

Identifiers

PMID40083193
PMCPMC12446727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.