Evidence map›Paper›PMID 40083186›Full record

ArticleInternational forum of allergy & rhinology2025

Associations of Historic Residential Pesticide Proximity With Proinflammatory Cytokine Levels in a Patient Population With and Without Chronic Rhinosinusitis (CRS).

Melodyanne Y Cheng, Kimberly C Paul, Jakob L Fischer, Myles G Cockburn, Laura K Thompson, Hong-Ho Yang, Jeffrey D Suh, Marilene B Wang, Jivianne T Lee

Abstract read
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In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melodyanne Y ChengDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-7081-1517
Kimberly C PaulDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Jakob L FischerDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Myles G CockburnNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Laura K ThompsonNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hong-Ho YangDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-2032-3141
Jeffrey D SuhDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Marilene B WangDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Jivianne T LeeDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Funding

Immune System Aging in Parkinson’s and Alzheimer’s disease: Epigenetics, biologic aging, and heightened immune states in a population-based studyK01AG072044 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KIMBERLY · 2021 to 2025
$717k
Congressionally Directed Medical Research Programs W81XWH-21-2-0048NIA NIH HHS K01 AG072044
6 · The paper itself

Abstract

backgroundResidential proximity to commercial pesticide application has been associated with increased odds of developing chronic rhinosinusitis (CRS) with in vitro studies demonstrating cytotoxic dose-dependent effects on sinonasal epithelia. This study's aim is to determine potential associations between residential proximity to commercial pesticide application sites and cytokine profiles in patients with and without CRS.

methodsA total of 55 patients were included (35 CRS and 20 control) with an average age of 55 ± 15 years. Ambient pesticide exposure was estimated through residential proximity to commercial pesticide applications using a validated computational geographic information system (GIS) algorithm. Sinonasal tissue samples were analyzed by an immune assessment core for 38 cytokine levels. Linear and logistic regression analysis was used to assess potential correlations between pesticide exposure and inflammatory cytokine levels.

resultsA total of 32 (58%) patients resided within 2000 m of any reported commercial pesticide application, including 12 (63%) of the CRSsNP group, 9 (56%) of the CRSwNP group, and 11 (56%) of the control group. Adjusted model 4, which controlled for all covariates listed above, demonstrated associations between pesticide exposure and IL-1α (p = 0.01), TNFβ (p = 0.03), IL-10 (p = 0.03), and IFNα-2 (p = 0.05). When examining CRS and non-CRS participants while stratifying for age, sex, race, smoking history, year of evaluation, and county of residence, an association was found between TNFβ and CRS (p = 0.03) and IL-1α and CRS (p = 0.01), but not IL-10 or IFNα-2 and CRS (p > 0.05).

conclusionThis study revealed residential proximity to commercial pesticide applications was associated with increased levels of proinflammatory/cytokines with several exposure associations stronger among CRS patients.

Indexed as

CytokinesEnvironmental ExposurePesticidesRhinitisSinusitisAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedRhinosinusitisCytokinesPesticideschronic rhinosinusitiscytokinesinflammationpesticides

Identifiers

PMID40083186
PMCPMC12315492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.