Evidence map›Paper›PMID 40083174›Full record

ArticleJournal of applied gerontology : the official journal of the Southern Gerontological Society2025

Linking Social Cohesion to Biological Markers of Aging: Evidence From the National Health and Aging Trends Study.

Tara C Klinedinst, Nicholas Hollman, Michael J Hankes, Raymond Jones

Abstract read
In one paragraph

Article in Journal of applied gerontology : the official journal of the Southern Gerontological Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tara C KlinedinstDepartment of Rehabilitation Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID 0000-0002-2560-4631
Nicholas HollmanOffice of Research Development and Scholarly Activity, OU-TU School of Community Medicine, Tulsa, OK.
Michael J HankesSchool of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Raymond JonesCenter for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9241-2309

Funding

The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults with HIV.K01AG086063 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Raymond Jones · 2024 to 2026
$378k
NIA NIH HHS K01 AG086063NIA NIH HHS U01 AG032947
6 · The paper itself

Abstract

Social cohesion, a measure of community belonging, and inflammatory biomarkers, like interleukin-6 (IL-6) and c-reactive protein (CRP), have emerged as significant factors influencing age-related chronic conditions and functional decline among older adults. Understanding the link between social cohesion and inflammation is particularly relevant in aging populations, as with age, social networks often diminish, and the prevalence of inflammatory conditions increases. Using data from the National Health and Aging Trends Study (NHATS), we assessed the relationship between low social cohesion and IL-6 and CRP. We found that low social cohesion was associated with higher levels of CRP and IL-6 after adjusting for the influence of sociodemographic variables. These findings could inform health policies and community-level interventions designed to enhance social cohesion for aging adults.

Indexed as

AgingC-Reactive ProteinInterleukin-6Social SupportAgedAged, 80 and overBiomarkersFemaleHumansInflammationMaleMiddle AgedUnited StatesBiomarkersC-Reactive ProteinInterleukin-6agingchronic conditionsinflammationsocial cohesion

Identifiers

PMID40083174
PMCPMC12268888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.