ArticleClinical and experimental pediatrics2025
Nonlinear association between neutrophil-to-lymphocyte ratio and asthma in children and adolescents in the United States: a cross-sectional study.
Article in Clinical and experimental pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A clinician-oriented machine learning model for adult asthma exacerbation prediction: comparative analysis of nine algorithms.Journal of thoracic disease · 2026Article
- The Role of NLR and Ferritin Levels as Biomarkers for Corticosteroid Dosage in Children with RefractoryJournal of inflammation research · 2026Article
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2 authors.
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Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with various diseases including respiratory conditions. However, the relationship between NLR and asthma in the pediatric population remains underexplored. PURPOSE: This study aimed to explore the association between NLR and asthma in children and adolescents and assess its potential role as a predictive biomarker for pediatric asthma.
methodsWe retrospectively analyzed the medical records of 12,974 children and adolescents from the National Health and Nutrition Examination Survey in 2011-2020. NLR was defined as the ratio of NLR counts. Asthma was diagnosed using a structured questionnaire. Multivariate logistic regression models were used to evaluate the association between NLR and asthma. A restricted cubic spline was used to explore nonlinear relationships, and a threshold analysis was conducted to identify potential cutoff values for the NLR.
resultsA total of 12,974 children and adolescents were included (male: 6,686 [51.5%]; mean [interquartile range] age, 10 [5.0-14.0 years]). After the adjustment for confounders, participants with the highest versus lowest NLR exhibited a significantly elevated risk of asthma (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.13-1.71). Additionally, a multivariate restricted cubic spline analysis revealed a nonlinear relationship between NLR and asthma (P=0.023). A threshold analysis revealed that an NLR<2.23 was significantly associated with an increased risk of asthma (OR, 1.23; 95% CI, 1.05-1.45), while an NLR≥2.23 showed no significant association. A subgroup analysis revealed no interactive role of NLR and asthma.
conclusionOur findings indicate a nonlinear saturation-effect relationship between NLR and asthma in children and adolescents.
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