ArticleMolecular plant pathology2025
Potato Type I Protease Inhibitor Mediates Host Defence Against Potato Virus X Infection by Interacting With a Viral RNA Silencing Suppressor.
Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Pathogenesis-Related Protein 4b Induced by Rice Stripe Virus Enhances Host's Antiviral Defence.Molecular plant pathology · 2026Article
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Advances in Plant Antiviral RNAi: From Host DCLs/RDRs to Diversified Viral Counteracting Strategies.Viruses · 2026Review
- Silencing of the Mycorrhiza-Inducible Phosphate TransporterPlants (Basel, Switzerland) · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
Counteracting plant RNA silencing ensures successful viral infection. The P25 protein encoded by potato virus X (PVX) is a multifunctional protein that acts as a viral RNA silencing suppressor (VSR). In this study, we screened out a potato type I protease inhibitor (PI) in Nicotiana benthamiana (NbPI) that interacts with P25. Silencing of NbPI by tobacco rattle virus (TRV)-mediated virus-induced gene silencing (VIGS) promoted the infection of PVX. Overexpression of NbPI in transgenic plants conferred resistance to PVX infection. Moreover, transient expression of NbPI impaired the VSR activity and cell-to-cell movement complementation ability of P25. Further experiments showed that P25 protein degradation was through the combination of autophagy and the ubiquitin-26S proteasome system (UPS), leading to impairment of P25. Taken together, we have identified NbPI as a new host factor that compromises PVX infection by targeting and degrading the VSR P25.
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