Evidence map›Paper›PMID 40083017›Full record

ArticleEuropean journal of medical research2025

Comparison of ROX index with modified indices incorporating heart rate, flow rate, and PaO

Smitesh Gutta, Wei Jun Dan Ong, Shanaz Matthew Sajeed, Belinda Zer Hui Chern, Monika Gulati Kansal, Faheem Ahmed Khan, Amit Kansal

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Smitesh GuttaDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore. smiteshg@gmail.com.
Wei Jun Dan OngDepartment of Respiratory Therapy, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.
Shanaz Matthew SajeedDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.
Belinda Zer Hui ChernDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.
Monika Gulati KansalDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.
Faheem Ahmed KhanDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.
Amit KansalDepartment of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, 1 Jurong East Street 21, Singapore, 609606, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncorporation of heart rate, flow rate, and PaO

methodsThis single-centre 6-year retrospective study included subjects initiated on HFNC post-extubation. The modified indices (ROX-HR, ROX-HR-Flow and POX-HR-Flow) incorporated HFNC flow rate, heart rate and substituted PF ratio for SF ratio. Evaluation was performed using AUROC and cut-offs assessed for prediction of HFNC outcomes.

resultsEighty-one subjects were initiated on HFNC post-extubation, of whom 67 patients (82.7%) had HFNC success. ROX-HR-Flow at 2 h post-HFNC initiation demonstrated the best prediction accuracy (AUROC 0.854, 95% CI 0.756-0.952). A ROX-HR-Flow > 12.25 at 2 h post-HFNC initiation was significantly associated with a lower risk of HFNC failure (Sensitivity 77.6% and Specificity 85.7%).

conclusionsOur proposed modified index at 2 h post-HFNC initiation (ROX-HR-Flow), may facilitate early and accurate prediction of HFNC outcomes compared to ROX index among subjects initiated on HFNC in the post-extubation setting.

Indexed as

Airway ExtubationCannulaHeart RateOxygen Inhalation TherapyAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAdult ICUHFNCHFNC failureIndicesPost-extubationRespiratory failure

Identifiers

PMID40083017
PMCPMC11907874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.