Evidence map›Paper›PMID 40082960›Full record

ArticleLipids in health and disease2025

The association between the atherogenic index of plasma and all-cause mortality in patients undergoing peritoneal dialysis: a multicenter cohort study.

Yaohua Hu, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Jian Li, Xinyang Li, Mengyuan Yu, Wenpeng Cui

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yaohua HuDepartment of Nephrology, The Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun, 130041, Jilin Province, China.
Liming YangDepartment of Nephrology, The First Hospital of Jilin University-the Eastern Division, Changchun, 130041, Jilin Province, China.
Zhanshan SunDepartment of Nephrology, Xing'anmeng People's Hospital, Ulan Hot 137400, Inner Mongolia Autonomous Region, China.
Xiaoxuan ZhangDepartment of Nephrology, Jilin FAW General Hospital, 130041, Changchun, Jilin Province, China.
Xueyan ZhuDepartment of Nephrology, Jilin Central Hospital, 132011, Jilin, Jilin Province, China.
Jian LiDepartment of Nephrology, The Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun, 130041, Jilin Province, China.
Xinyang LiDepartment of Nephrology, The Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun, 130041, Jilin Province, China.
Mengyuan YuDepartment of Nephrology, The Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun, 130041, Jilin Province, China.
Wenpeng CuiDepartment of Nephrology, The Second Hospital of Jilin University, No. 4026 Yatai Street, Changchun, 130041, Jilin Province, China. wenpengcui@163.com.

Funding

Jilin Provincial Scientific and Technological Development Program YDZJ202201ZYTS110
6 · The paper itself

Abstract

backgroundThe Atherogenic Index of Plasma (AIP) has been reported as a strong predictor of all-cause mortality in the overall population. However, the lipid profile changes in individuals with end-stage kidney disease (ESKD) undergoing peritoneal dialysis (PD) may affect the prognostic utility of AIP for all-cause mortality. The connection between them remains unclear.

methodsThis study included patients receiving PD at five hospitals in China from January 1, 2013, to December 31, 2019, with follow-up until June 30, 2020. The primary exposure variable in this investigation was the logarithm of the triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, which was used to compute the AIP, and the outcome variable was all-cause mortality. A Cox proportional hazards regression model was employed to analyze the association between AIP and all-cause mortality. Moreover, stratified analyses were performed to investigate this association further. Kaplan-Meier curves were employed for survival analysis, assessing the prognostic implications of varying AIP levels. Nonlinear associations were examined using smooth curve fitting techniques.

resultsA total of 869 patients were included in this study, of whom 153 died during the follow-up period. An inverse association was observed between AIP and all-cause mortality risk in the highest tertile compared to the lowest tertile (HR: 0.56, 95% CI: 0.37-0.84) after correcting for potential confounding variables. Moreover, a nonlinear association was observed between the rates of all-cause mortality and AIP. A segmented Cox regression model identified an inflection point at an AIP value of 0.63 (P = 0.014 for the log-likelihood ratio test). More specifically, it was negatively associated with the all-cause mortality risk (HR: 0.42, 95% CI: 0.25-0.73, P = 0.002) when AIP was ≤ 0.63. On the other hand, AIP showed a positive association with the risk of all-cause mortality when it was more than 0.63 (HR: 8.94, 95% CI: 1.66-48.10, P = 0.011).

conclusionThe present study identified a non-linear association between AIP and all-cause mortality in patients receiving peritoneal dialysis.

Indexed as

AtherosclerosisCholesterol, HDLKidney Failure, ChronicPeritoneal DialysisTriglyceridesAdultAgedChinaCohort StudiesFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsCholesterol, HDLTriglyceridesAll-cause mortalityAtherogenic index of plasmaPeritoneal dialysis

Identifiers

PMID40082960
PMCPMC11905527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.