ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025
Development and evaluation of a deep learning framework for pelvic and sacral tumor segmentation from multi-sequence MRI: a retrospective study.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Bilateral presacral tumors in an adult female patient: A case report and literature review.Experimental and therapeutic medicine · 2026Article
- Deep learning segmentation of paediatric brain tumours using diffusion-weighted MRI: towards an early,Brain communications · 2026Article
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8 authors.
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Abstract
backgroundAccurate segmentation of pelvic and sacral tumors (PSTs) in multi-sequence magnetic resonance imaging (MRI) is essential for effective treatment and surgical planning. PURPOSE: To develop a deep learning (DL) framework for efficient segmentation of PSTs from multi-sequence MRI. MATERIALS AND
methodsThis study included a total of 616 patients with pathologically confirmed PSTs between April 2011 to May 2022. We proposed a practical DL framework that integrates a 2.5D U-net and MobileNetV2 for automatic PST segmentation with a fast annotation strategy across multiple MRI sequences, including T1-weighted (T1-w), T2-weighted (T2-w), diffusion-weighted imaging (DWI), and contrast-enhanced T1-weighted (CET1-w). Two distinct models, the All-sequence segmentation model and the T2-fusion segmentation model, were developed. During the implementation of our DL models, all regions of interest (ROIs) in the training set were coarse labeled, and ROIs in the test set were fine labeled. Dice score and intersection over union (IoU) were used to evaluate model performance.
resultsThe 2.5D MobileNetV2 architecture demonstrated improved segmentation performance compared to 2D and 3D U-Net models, with a Dice score of 0.741 and an IoU of 0.615. The All-sequence model, which was trained using a fusion of four MRI sequences (T1-w, CET1-w, T2-w, and DWI), exhibited superior performance with Dice scores of 0.659 for T1-w, 0.763 for CET1-w, 0.819 for T2-w, and 0.723 for DWI as inputs. In contrast, the T2-fusion segmentation model, which used T2-w and CET1-w sequences as inputs, achieved a Dice score of 0.833 and an IoU value of 0.719.
conclusionsIn this study, we developed a practical DL framework for PST segmentation via multi-sequence MRI, which reduces the dependence on data annotation. These models offer solutions for various clinical scenarios and have significant potential for wide-ranging applications.
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