Evidence map›Paper›PMID 40082922›Full record

ArticleTrials2025

Empowerment and mobile technology in the detection and treatment of main cardiovascular risk factors of patients with ischemic stroke or transient ischemic attack: a protocol for a multicenter randomized controlled trial (CARDIOSTROKE).

T Lumikari, J Putaala, J Pirinen, A Kerola, G Sibolt, Hanna Granroth-Wilding, S Pakarinen, M Lehto, T Nieminen

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03710902 (Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03710902 narecruitingnot on this map

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

TypeinterventionalSponsorJukka PutaalaRan2018 to 2028Enrolled405ConditionsIschemic Stroke, Transient Ischemic Attack, Atrial Fibrillation, HypertensionArmsECG monitoring for 3 weeks, Self-monitoring of BP and self-titration of antihypertensive medication
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T LumikariDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Tuomas.lumikari@helsinki.fi.
J PutaalaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
J PirinenHeart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
A KerolaDepartment of Rheumatology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
G SiboltDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Hanna Granroth-WildingBiostatistics Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
S PakarinenJorvi Hospital, HUS Helsinki University Hospital and University of Helsinki, Espoo, Finland.
M LehtoJorvi Hospital, HUS Helsinki University Hospital and University of Helsinki, Espoo, Finland.
T NieminenPäijät-Häme Wellbeing Services County, Lahti, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension and atrial fibrillation (AF) are major treatable risk factors for ischemic stroke and transient ischemic attack (TIA). However, most of the patients with an ischemic stroke or TIA fail to reach desired blood pressure (BP) control and AF remains underdiagnosed with standard ECG monitoring. The aim of the CARDIOSTROKE study is to (1) test the effect of 3-week non-invasive ECG monitoring combined with (2) self-monitoring of BP and (3) patient-controlled titration of antihypertensives over 12 months in patients with recent non-cardioembolic ischemic stroke or TIA.

methodsCARDIOSTROKE is an investigator-initiated, multicenter, open, prospective trial aiming to randomize patients with recent (within 1 month) ischemic stroke or TIA to receive in a 2:1 fashion either (1) standard diagnostic work-up and follow-up (control arm) or (2) 3-week ECG monitoring combined with self-monitoring of BP and mobile-device-assisted self-titration of antihypertensives (intervention arm). The co-primary outcomes are (1) mean reduction in systolic BP and (2) detection of new AF at 12 months. DISCUSSION: Mobile technology assisted control of the two major risk factors of stroke recurrence has not previously been studied in patients with recent stroke or TIA, which supports conducting a randomized trial in this patient population.

trial registrationClinicalTrials.gov NCT03710902. Registered on October 16, 2018.

Indexed as

Antihypertensive AgentsAtrial FibrillationHypertensionIschemic Attack, TransientIschemic StrokeMobile ApplicationsBlood PressureBlood Pressure Monitoring, AmbulatoryElectrocardiography, AmbulatoryHeart Disease Risk FactorsHumansMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicRisk FactorsTelemedicineAntihypertensive AgentsAtrial fibrillationBlood pressureElectrocardiogramEmpowermentHypertensionIschemic strokeMobile technologyTransient ischemic attack

Identifiers

PMID40082922
PMCPMC11907936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.