Evidence map›Paper›PMID 40082846›Full record

SynthesisBMC urology2025

Neutrophil to lymphocyte ratio in urolithiasis: a systematic review.

Shokoufeh Khanzadeh, Fatemeh Zarimeidani, Erfan Kashani, Saghar Babadi, Rahem Rahmati, Brandon Lucke-Wold, John Cerillo, Arshin Ghaedi

Abstract readSystematic Review
In one paragraph

Synthesis in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shokoufeh KhanzadehTabriz University of Medical Sciences, Tabriz, Iran.
Fatemeh ZarimeidaniStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran. fatemeh.zarimeidani@yahoo.com.
Erfan KashaniDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Arak University of Medical Sciences, Arak, Iran.
Saghar BabadiStudent Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Rahem RahmatiStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, USA.
John CerilloNova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Tampa Bay Regional Campus, Gulf to Bay Blvd, Clearwater, FL, 3375, USA.
Arshin GhaediStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrolithiasis is among the most prevalent and possibly devastating diseases. It affects millions worldwide, and a cheap or rapid biomarker is required to diagnose it. Previous investigations revealed that inflammation has a role in the progression of urolithiasis patients, and an elevated neutrophil-to-lymphocyte ratio (NLR) value can be a valuable biomarker to ensure inflammation and, consequently, renal stones. This study was conducted to summarize the results of studies investigating the role of NLR in urolithiasis.

methodsWe systematically searched three main databases (Scopus, PubMed, and Web of Science) up to January 1, 2023. Our study was registered in PROSPERO (CRD42024500756).

resultsUltimately, 33 studies were selected for this review article. Patients in either acute or subacute phase exhibited higher NLR levels than healthy controls. Also, patients in acute and subacute phases significantly differed regarding NLR levels. In addition, studies showed that NLR could predict sepsis and systemic inflammatory response syndrome (SIRS) among urolithiasis patients. In addition, evidence reported that NLR was helpful in the prediction of spontaneous stone passage among these patients.

conclusionOur results support a reliable biomarker that is easily added into clinical settings to help predict urolithiasis patients' condition.

Indexed as

LymphocytesNeutrophilsUrolithiasisBiomarkersHumansLeukocyte CountBiomarkersNeutrophil to lymphocyte ratioSystematic reviewUrolithiasis

Identifiers

PMID40082846
PMCPMC11905559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.