Evidence map›Paper›PMID 40082821›Full record

ArticleBMC cancer2025

Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors.

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Haojiong Zhang, Jiade Jay Lu, Lin Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qingting Huang *Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, 4365 Kangxin Road, Pudong, Shanghai, 201321, China.
Jiyi Hu *Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, 4365 Kangxin Road, Pudong, Shanghai, 201321, China.
Weixu HuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, 201321, China.
Jing GaoDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, 201321, China.
Haojiong ZhangDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, 201321, China.
Jiade Jay LuDepartment of Radiation Oncology, Proton and Heavy Ion Center, Heyou International Hospital, Foshan, 523000, China. jiadelu@yahoo.com.
Lin KongDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, 4365 Kangxin Road, Pudong, Shanghai, 201321, China. linkong1152@163.com.

Funding

the Health research project of Pudong New Area Health Commission PW2024B-08the Key research and development Program of the Ministry of Science and Technology 2022YFC2401505the Science and Technology Development Fund of Shanghai Pudong New Area PKJ2020-Y53the Shanghai Municipal Health Commission Clinical research project 20224Y0062
6 · The paper itself

Abstract

backgroundMajor salivary gland tumors (MSGTs) are rare and pose significant treatment challenges. This study investigates the efficacy and safety of particle beam radiotherapy (PBRT) for patients with newly-diagnosed MSGTs.

methodsWe conducted a retrospective analysis of 82 patients treated at the Shanghai Proton and Heavy Ion Center (SPHIC) between August 2015 and March 2022. The cohort received various radiotherapy regimens based on surgical history and pathological risk factors. We evaluated survival outcomes, treatment toxicity, and potential prognostic factors.

resultsOur findings revealed promising 3-year survival rates: 94.3% for overall survival (OS), 81.3% for progression-free survival (PFS), 97.2% for locoregional control (LRC), and 82.6% for distant metastasis-free survival (DMFS). Acute and late toxicities were generally mild to moderate, with a favorable safety profile. Distant metastasis was the primary mode of treatment failure, emphasizing the need for early risk assessment.

conclusionAs a potentially safe and efficient treatment option for newly-diagnosed MSGTs, proton and carbon ion radiation offers an excellent alternative for traditional methods. More investigation is required to determine the long-term results and relative efficacy of various treatment modality for major salivary gland cancer when compared to photon therapy.

Indexed as

Heavy Ion RadiotherapyProton TherapySalivary Gland NeoplasmsAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateTreatment OutcomeYoung AdultCarbon ionInitial clinical outcomesMajor salivary gland carcinomaNewly-diagnosedProton

Identifiers

PMID40082821
PMCPMC11905503

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.